ArticleJournal of the American Statistical Association2020
Optimal Designs of Two-Phase Studies.
Article in Journal of the American Statistical Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
- Overcoming data challenges through enriched validation and targeted sampling to measure whole-person health in electronic health records.Journal of biomedical informatics · 2025Article
- Valid and efficient inference for nonparametric variable importance in two-phase studies.Biometrics · 2025Article
- Performance of Two-Phase Designs for the Time-to-Event Outcome and a Case Study Assessing the Relapse Risk Associated With B-ALL Subtypes.JCO clinical cancer informatics · 2025Article
- Optimum Allocation for Adaptive Multi-Wave Sampling in R: The R Package optimall.Journal of statistical software · 2025Article
- A SEMIPARAMETRIC METHOD FOR RISK PREDICTION USING INTEGRATED ELECTRONIC HEALTH RECORD DATA.The annals of applied statistics · 2024Article
- Study design features increase replicability in cross-sectional and longitudinal brain-wide association studies.bioRxiv : the preprint server for biology · 2024Article
- Optimal multiwave validation of secondary use data with outcome and exposure misclassification.The Canadian journal of statistics = Revue canadienne de statistique · 2024Article
- Association analysis of self-reported outcomes with a validated subset.Statistics in medicine · 2024Article
- Article
- Article
- Semi-supervised calibration of noisy event risk (SCANER) with electronic health records.Journal of biomedical informatics · 2023Article
- Two-phase stratified sampling and analysis for predicting binary outcomes.Biostatistics (Oxford, England) · 2023Article
- Two-phase sample selection strategies for design and analysis in post-genome-wide association fine-mapping studies.Statistics in medicine · 2021Article
- Two-Phase Sampling Designs for Data Validation in Settings with Covariate Measurement Error and Continuous Outcome.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2021Article
- Optimal allocation in stratified cluster-based outcome-dependent sampling designs.Statistics in medicine · 2021Article
- Two-wave two-phase outcome-dependent sampling designs, with applications to longitudinal binary data.Statistics in medicine · 2021Article
- A novel age-informed approach for genetic association analysis in Alzheimer's disease.Alzheimer's research & therapy · 2021Article
- Efficient semiparametric inference for two-phase studies with outcome and covariate measurement errors.Statistics in medicine · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The two-phase design is a cost-effective sampling strategy to evaluate the effects of covariates on an outcome when certain covariates are too expensive to be measured on all study subjects. Under such a design, the outcome and inexpensive covariates are measured on all subjects in the first phase and the first-phase information is used to select subjects for measurements of expensive covariates in the second phase. Previous research on two-phase studies has focused largely on the inference procedures rather than the design aspects. We investigate the design efficiency of the two-phase study, as measured by the semiparametric efficiency bound for estimating the regression coefficients of expensive covariates. We consider general two-phase studies, where the outcome variable can be continuous, discrete, or censored, and the second-phase sampling can depend on the first-phase data in any manner. We develop optimal or approximately optimal two-phase designs, which can be substantially more efficient than the existing designs. We demonstrate the improvements of the new designs over the existing ones through extensive simulation studies and two large medical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.