Evidence map›Paper›PMID 33716288›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Pheochromocytoma Diagnosed during the Treatment of Diffuse Alveolar Hemorrhage, a Diagnostic Necessity before Using High-dose Glucocorticoids.

Masahiro Nezu, Hiroaki Kobayashi, Masashi Shiozaki, Miho Katsumata, Soichi Takizawa, Toshiharu Tsutsui, Ikuo Nukui, Yoshihiro Miyashita, Toshio Oyama, Masaharu Inoue

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Potentially fatal crisis afterEndocrine journal · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Masahiro NezuDepartment of Endocrinology and Diabetes, Yamanashi Prefectural Central Hospital, Japan.
Hiroaki KobayashiDepartment of Pulmonary Medicine, Yamanashi Prefectural Central Hospital, Japan.
Masashi ShiozakiDepartment of Urology, Yamanashi Prefectural Central Hospital, Japan.
Miho KatsumataDepartment of Endocrinology and Diabetes, Yamanashi Prefectural Central Hospital, Japan.
Soichi TakizawaDepartment of Endocrinology and Diabetes, Yamanashi Prefectural Central Hospital, Japan.
Toshiharu TsutsuiDepartment of Pulmonary Medicine, Yamanashi Prefectural Central Hospital, Japan.
Ikuo NukuiDepartment of Nephrology, Yamanashi Prefectural Central Hospital, Japan.
Yoshihiro MiyashitaDepartment of Pulmonary Medicine, Yamanashi Prefectural Central Hospital, Japan.
Toshio OyamaDepartment of Pathology, Yamanashi Prefectural Central Hospital, Japan.
Masaharu InoueDepartment of Endocrinology and Diabetes, Yamanashi Prefectural Central Hospital, Japan.
Yamanashi Prefectural Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 46-year-old woman with exacerbating hemoptysis and dyspnea was diagnosed with diffuse alveolar hemorrhage (DAH). High doses of glucocorticoids were initiated, but afterward, paroxysmal hypertension (210/140 mmHg) with headache and abdominal pain appeared. A 50-mm left adrenal tumor with an intense uptake by iodine-123 metaiodobenzylguanidine scintigraphy and catecholamine hypersecretion revealed complication with pheochromocytoma. Because high doses of glucocorticoids, sometimes required for DAH, can provoke life-threatening paroxysmal hypertension in pheochromocytoma and paraganglioma (PPGL), our case suggests that PPGL needs to be recognized as the cause of DAH and should be detected with whole-body imaging before starting glucocorticoids.

Indexed as

Adrenal Gland NeoplasmsParagangliomaPheochromocytomaFemaleGlucocorticoidsHemorrhageHumansMiddle AgedGlucocorticoidscatecholamine crisisdiffuse alveolar hemorrhagehigh-dose glucocorticoidspheochromocytoma

Identifiers

PMID33716288
PMCPMC8479232
OpenAlexW3136970262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.