ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Paediatric tuberculosis - new advances to close persistent gaps.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Diagnostic accuracy of the WHO tuberculosis treatment decision algorithms for children with presumptive tuberculosis: An individual participant data meta-analysis.PLoS medicine · 2025Pooled it
- Effect of integrating paediatric tuberculosis services into child healthcare services on case detection in Africa: the INPUT stepped-wedge cluster-randomised trial.BMJ global health · 2024Trial
- Age and sex differences in paediatric tuberculosis care for child contacts.Journal of global health · 2026Article
- Comparison of stool and gastric content samples analyzed with genexpert ultra for the diagnosis of pulmonary tuberculosis in children under five in Niger: a multi-center diagnostic study.BMC microbiology · 2026Article
- Pediatric pulmonary and extrapulmonary tuberculosis: immunological and diagnostic perspectives.BMC infectious diseases · 2026Article
- Centrifugation Versus Centrifugation-Free Stool Processing: Can the Simple One-Step Method Reliably Diagnose Pediatric Pulmonary Tuberculosis Using Xpert MTB/RIF Ultra?Diagnostics (Basel, Switzerland) · 2026Article
- Missed opportunity for tuberculosis screening and prevention and the associated factors among child contacts in rural southwestern Uganda.BMC pulmonary medicine · 2025Article
- Patterns and Cofactors of Polyfunctional Mycobacteria-Specific T-Cell Response Restoration Following 6-Month Antiretroviral Treatment in Children With HIV.The Journal of infectious diseases · 2025Article
- Community-Based Tuberculosis Preventive Treatment Among Child and Adolescent Household Contacts in Ethiopia.Tropical medicine and infectious disease · 2025Article
- Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis.The Journal of infectious diseases · 2024Article
- Prevalence and Associated Factors of Children Tuberculosis in Southeast Asia Countries: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2024Review
- Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life: a South African birth cohort study.The Lancet. Child & adolescent health · 2024Article
- Stool XpertIJTLD open · 2024Article
- Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment.Gut pathogens · 2024Article
- Improving TB detection among children in routine clinical care through intensified case finding in facility-based child health entry points and decentralized management: A before-and-after study in Nine Sub-Saharan African Countries.PLOS global public health · 2024Article
- "It's about time they taught us": a qualitative study evaluating the barriers to finding and screening child contacts under five at risk for TB in Gauteng Province, South Africa from the provider and caregiver perspectives.BMC health services research · 2023Article
- Critical Review of Tuberculosis Diagnosis in Children from Papua New Guinea Presenting to Health Facilities in the Torres Strait Islands, Australia.Microorganisms · 2023Article
- Revealing Gaps in Our Understanding of Finding Children With TB and Our Ability to Inform Policy.Pediatrics · 2023Article
- UMOYA: a prospective longitudinal cohort study to evaluate novel diagnostic tools and to assess long-term impact on lung health in South African children with presumptive pulmonary TB-a study protocol.BMC pulmonary medicine · 2023Article
- Optimizing DNA Extraction from Pediatric Stool for Diagnosis of Tuberculosis and Use in Next-Generation Sequencing Applications.Microbiology spectrum · 2023Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 8 countries.
Funding
Abstract
Young children are most vulnerable to develop severe forms of tuberculosis (TB) and are over-represented among TB deaths. Almost all children estimated to have died from TB were never diagnosed or offered TB treatment. Improved access to TB preventive treatment (TPT) requires major upscaling of household contact investigation with allocation of adequate resources. Symptom-based screening is often discouraged in adults for fear of generating drug resistance, if TB cases are missed. However, the situation in vulnerable young children is different, as they present minimal risk of drug resistance generation. Further, the perceived need for additional diagnostic evaluation presents a major barrier to TPT access and underlies general reluctance to consider pragmatic decentralised models of care. Widespread roll-out of Xpert MTB/RIF Ultra® represents an opportunity for improved case detection in young children, but attaining full impact will require the use of non-sputum specimens. The new Fujifilm SILVAMP TB LAM® urine assay demonstrated good diagnostic accuracy in HIV-positive and malnourished children, but further validation is required. Given the limited accuracy of all available tests and the excellent tolerance of TB drugs in children, the global community may have to accept some over-treatment if we want to close the persistent case detection gap in young children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.