ArticleNeuroImage2021
Cerebrovascular reactivity measurements using simultaneous
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Oxygen extraction fraction (OEF) values and applications in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Measuring Quantitative Cerebral Blood Flow in Healthy Children: A Systematic Review of Neuroimaging Techniques.Journal of magnetic resonance imaging : JMRI · 2024Pooled it
- Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniquesJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Pooled it
- Assessment of cerebrovascular reactivity in middle cerebral artery stenosis using non-hypercapnic resting-state fMRI: a potential biomarker for hemodynamic alterations.BMC medical imaging · 2026Article
- A parameterized gamma-variate function can describe the temporal response of cerebral blood flow after Acetazolamide injection in Moyamoya patients.Neuroimage. Reports · 2026Article
- Simultaneous multiple post-labelling delay ASL MRI and [European journal of nuclear medicine and molecular imaging · 2026Article
- Cerebral Hyperperfusion Syndrome Following Dural Arteriovenous Fistula Embolization: The Paradoxical Findings In Arterial Spin Labeling MRI and 123I-iodoamphetamine SPECT.Clinical neuroradiology · 2025Article
- Benefits and challenges of multi-delay arterial spin labeling in clinical practice: measuring perfusion and cerebrovascular reactivity in intracranial steno-occlusive disease.Insights into imaging · 2025Article
- Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.Experimental physiology · 2025Review
- The Effect of Diagnostic Hypercapnic Cerebrovascular Reactivity Imaging on Vital Signs and Acute and Follow-Up Ischemic Adverse Events in Patients with Flow-Limiting Intracranial Arterial Stenosis.AJNR. American journal of neuroradiology · 2025Article
- Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Problems and solutions in quantifying cerebrovascular reactivity using BOLD-MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Evaluating cerebrovascular reactivity measured by velocity selective inversion arterial spin labeling with different post-labeling delays: The effect of fast flow.Magnetic resonance in medicine · 2024Article
- Assessing Mild Traumatic Brain Injury-Associated Blood-Brain Barrier (BBB) Damage and Restoration Using Late-Phase Perfusion Analysis by 3D ASL MRI: Implications for Predicting Progressive Brain Injury in a Focused Review.International journal of molecular sciences · 2024Review
- Exploring the Impact of Hemoglobin on Cerebral Blood Flow in Arterial Territories and Surgical Outcomes: Potential Implications for Moyamoya Disease Treatment.Journal of the American Heart Association · 2024Article
- Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.Magnetic resonance in medicine · 2024Review
- Turning brain MRI into diagnostic PET:Medical image analysis · 2024Article
- The Quest of Characterizing Hemodynamic Failure in Patients With Cerebrovascular Disease.Journal of the American Heart Association · 2023Article
- Revascularization improves vascular hemodynamics - a study assessing cerebrovascular reserve and transit time in Moyamoya patients using MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Transforming breast reconstruction: the pioneering role of artificial intelligence in preoperative planning.Gland surgery · 2023Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
Abstract
Cerebrovascular reactivity (CVR) reflects the capacity of the brain to meet changing physiological demands and can predict the risk of cerebrovascular diseases. CVR can be obtained by measuring the change in cerebral blood flow (CBF) during a brain stress test where CBF is altered by a vasodilator such as acetazolamide. Although the gold standard to quantify CBF is PET imaging, the procedure is invasive and inaccessible to most patients. Arterial spin labeling (ASL) is a non-invasive and quantitative MRI method to measure CBF, and a consensus guideline has been published for the clinical application of ASL. Despite single post labeling delay (PLD) pseudo-continuous ASL (PCASL) being the recommended ASL technique for CBF quantification, it is sensitive to variations to the arterial transit time (ATT) and labeling efficiency induced by the vasodilator in CVR studies. Multi-PLD ASL controls for the changes in ATT, and velocity selective ASL is in theory insensitive to both ATT and labeling efficiency. Here we investigate CVR using simultaneous
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.