Evidence map›Paper›PMID 33716137›Full record

ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2021

Lysobisphosphatidic acid (LBPA) enrichment promotes cholesterol egress via exosomes in Niemann Pick type C1 deficient cells.

Olga Ilnytska, Maciej Jeziorek, Kimberly Lai, Nihal Altan-Bonnet, Radek Dobrowolski, Judith Storch

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  14. A kaleidoscopic view of extracellular vesicles in lysosomal storage disorders.Extracellular vesicles and circulating nucleic acids · 2022
    Review
  15. Pathways and Mechanisms of Cellular Cholesterol Efflux-Insight From Imaging.Frontiers in cell and developmental biology · 2022
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olga IlnytskaDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA; Rutgers Center for Lipid Research, Institute for Food Nutrition and Health, Rutgers University, New Brunswick, NJ 08901, USA.
Maciej JeziorekDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
Kimberly LaiDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Nihal Altan-BonnetLaboratory of Host-Pathogen Dynamics, National Heart, Lung and Blood Institute, Bethesda, MD 20814, USA.
Radek DobrowolskiRutgers Center for Lipid Research, Institute for Food Nutrition and Health, Rutgers University, New Brunswick, NJ 08901, USA; Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
Judith StorchDepartment of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA; Rutgers Center for Lipid Research, Institute for Food Nutrition and Health, Rutgers University, New Brunswick, NJ 08901, USA. Electronic address: storch@sebs.rutgers.edu.

Funding

Virus Egress PathwaysZIAHL006234 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ALTAN-BONNET, NIHAL · 2017 to 2025
$21.8M
Regulation of Neuronal Clearance Pathways via Nuclear Calcium Signaling in Alzheimer's DiseaseR01AG062475 · NIA · RUTGERS THE STATE UNIV OF NJ NEWARK · PI FRIEDMAN, WILMA J · 2019 to 2023
$2.3M
Mechanisms of Cholesterol Transport by NPC ProteinsR01GM115866 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI STORCH, JUDITH · 2016 to 2019
$1.1M
Mucolipin-1-Mediated Mechanisms of Neuronal Clearance in Alzheimer’s DiseaseR56AG061040 · NIA · RUTGERS THE STATE UNIV OF NJ NEWARK · PI KIM, HAESUN A · 2019 to 2019
$385k
NIA NIH HHS R01 AG062475NIA NIH HHS R56 AG061040NIGMS NIH HHS R01 GM115866
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CholesterolExosomesLysophospholipidsAnimalsHumansMonoglyceridesNiemann-Pick C1 ProteinNiemann-Pick Disease, Type Cbis(monoacylglyceryl)phosphateCholesterolLysophospholipidsMonoglyceridesNiemann-Pick C1 ProteinBis(monoacylglycero)phosphateCholesterolExosomesExtracellular vesiclesLysobisphosphatidic acidNiemann-Pick C diseasePhosphatidylglycerol

Identifiers

PMID33716137
PMCPMC8038758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.