Evidence map›Paper›PMID 33716023›Full record

ArticleChemistry and physics of lipids2021

Application of DNP-enhanced solid-state NMR to studies of amyloid-β peptide interaction with lipid membranes.

Thomas Deo, Qinghui Cheng, Subhadip Paul, Wei Qiang, Alexey Potapov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry and physics of lipids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Investigation of biomolecular dynamics by sensitivity-enhancedJournal of magnetic resonance open · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Thomas DeoSchool of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Qinghui ChengDepartment of Chemistry, Binghamton University, the State University of New York, Binghamton, NY, 13902, USA.
Subhadip PaulSchool of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Wei QiangDepartment of Chemistry, Binghamton University, the State University of New York, Binghamton, NY, 13902, USA.
Alexey PotapovSchool of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. Electronic address: alexey.potapov@nottingham.ac.uk.
University of Nottingham · GBBinghamton University · US

Funding

Molecular Structural Basis of Non-specific Neuronal Membrane Disruption Induced by Early-Stage Beta-Amyloid Peptide AggregationR01GM125853 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI Wei Qiang · 2018 to 2026
$2.5M
NIGMS NIH HHS R01 GM125853
6 · The paper itself

Abstract

The cellular membrane disruption induced by the aggregation of Aβ peptide has been proposed as a plausible cause of neuronal cell death during Alzheimer's disease. The molecular-level details of the Aβ interaction with cellular membranes were previously probed using solid state NMR (ssNMR), however, due to the limited sensitivity of the latter, studies were limited to samples with high Aβ-to-lipid ratio. The dynamic nuclear polarization (DNP) is a technique for increasing the sensitivity of NMR. In this work we demonstrate the feasibility of DNP-enhanced ssNMR studies of Aβ

Indexed as

Nuclear Magnetic Resonance, BiomolecularAmyloid beta-PeptidesHydrophobic and Hydrophilic InteractionsLiposomesMembrane LipidsAmyloid beta-PeptidesLiposomesMembrane LipidsBeta-amyloid peptidesDynamic nuclear polarizationMembranesSolid-state NMR spectroscopy

Identifiers

PMID33716023
PMCPMC8022895
OpenAlexW3138362028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.