ArticleBiological psychiatry2021
Nucleus Accumbens Medium Spiny Neuron Subtypes Differentially Regulate Stress-Associated Alterations in Sleep Architecture.
Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Stress-induced adaptations in nucleus accumbens dopamine D1 receptor-expressing cells correspond to social avoidance behavior in male mice.IBRO neuroscience reports · 2026Article
- Vicarious defeat stress (VDS) is not a simple substitute for chronic social defeat stress (CSDS): a comparative study on behavioral and molecular mechanisms in both stress-induced anxiety- and depression-like behaviors.Behavioral and brain functions : BBF · 2026Article
- Motivation meets sleep: tuning arousal via nucleus accumbens and Basal Ganglia circuits.Npj biological timing and sleep · 2025Review
- Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress.Translational psychiatry · 2025Article
- Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- How dopamine guides our social world.Pharmacological reviews · 2025Review
- Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine-D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture.Human brain mapping · 2025Article
- Mapping the cellular etiology of schizophrenia and complex brain phenotypes.Nature neuroscience · 2025Article
- Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders.Fundamental research · 2025Review
- Acute sleep disruption reduces fear memories in male and female mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice.Addiction neuroscience · 2024Article
- Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State.Neuroscience bulletin · 2024Article
- Acute sleep deprivation reduces fear memories in male and female mice.bioRxiv : the preprint server for biology · 2024Article
- Differential effects of the stress peptides PACAP and CRF on sleep architecture in mice.NPP - digital psychiatry and neuroscience · 2024Article
- Early developmental changes in GABAA receptor expression in nucleus accumbens medium spiny neurons.Frontiers in neuroscience · 2024Article
- Dopamine D1-receptor-expressing pathway from the nucleus accumbens to ventral pallidum-mediated sevoflurane anesthesia in mice.CNS neuroscience & therapeutics · 2023Article
- Early life stress in male mice blunts responsiveness in a translationally-relevant reward task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- GABAergic Neurons in the Nucleus Accumbens are Involved in the General Anesthesia Effect of Propofol.Molecular neurobiology · 2023Article
- Central regulation of stress-evoked peripheral immune responses.Nature reviews. Neuroscience · 2023Review
- Involvement of brain cell phenotypes in stress-vulnerability and resilience.Frontiers in neuroscience · 2023Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStress is implicated in the pathophysiology of major depression and posttraumatic stress disorder. These conditions share core features, including motivational deficits, heighted anxiety, and sleep dysregulation. Chronic stress produces these same features in rodents, with some individuals being susceptible or resilient, as seen in humans. While stress-induced neuroadaptations within the nucleus accumbens are implicated in susceptibility-related dysregulation of motivational and emotional behaviors, their effects on sleep are unclear.
methodsWe used chemogenetics (DREADDs [designer receptors exclusively activated by designer drugs]) to examine the effects of selective alterations in activity of nucleus accumbens medium spiny neurons expressing dopamine D
resultsD1- and D2-MSNs play dissociable roles in sleep regulation. Stimulation of inhibitory or excitatory DREADDs expressed in D1-MSNs exclusively affects rapid eye movement sleep, whereas targeting D2-MSNs affects slow wave sleep. The combined effects of D1-MSN inhibition and D2-MSN activation on sleep resemble those of chronic social defeat stress. Alterations in D1-MSN function also affect stress susceptibility in social behavior tests. Elevation of CREB (cAMP response element-binding protein) within D1-MSNs is sufficient to produce stress-like effects on rapid eye movement sleep.
conclusionsIn addition to regulation of motivational and emotional behaviors, the nucleus accumbens also influences sleep, an end point with high translational relevance. These findings provide a neural basis for comorbidity in key features of stress-related illness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.