Evidence map›Paper›PMID 33715626›Full record

ArticleBMC medicine2021

A follow-up study shows that recovered patients with re-positive PCR test in Wuhan may not be infectious.

Xiaomin Wu, Zengmiao Wang, Zhenyu He, Yapin Li, Yating Wu, Huaiji Wang, Yonghong Liu, Fanghua Hao, Huaiyu Tian

Abstract read
In one paragraph

Article in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  14. The Illness Experience of Long COVID Patients: A Qualitative Study Based on the Online Q&A Community Zhihu.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaomin Wu *Wuhan Center for Disease Control and Prevention, Wuhan, China.
Zengmiao Wang *State Key Laboratory of Remote Sensing Science, Center for Global Change and Public Health, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China. wangzengmiao@gmail.com.
Zhenyu He *Wuhan Center for Disease Control and Prevention, Wuhan, China. hosan9174@163.com.
Yapin Li *Central Theater Center for Disease Control and Prevention of PLA, Beijing, China.
Yating WuWuhan Center for Disease Control and Prevention, Wuhan, China.
Huaiji WangWuhan Center for Disease Control and Prevention, Wuhan, China.
Yonghong LiuState Key Laboratory of Remote Sensing Science, Center for Global Change and Public Health, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China.
Fanghua HaoCentral China Normal University, Wuhan, China.
Huaiyu Tian *State Key Laboratory of Remote Sensing Science, Center for Global Change and Public Health, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China.

Funding

Beijing Natural Science Foundation JQ18025Beijing Science and Technology Planning Project Z201100005420010National Natural Science Foundation of China 82073616the Major Prevention Projects of Hubei Province Health Committee WJ2019H303Young Elite Scientist Sponsorship Program by CAST (YESS) 2018QNRC001
6 · The paper itself

Abstract

backgroundPrevious studies showed that recovered coronavirus disease 2019 (COVID-19) patients can have a subsequent positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after they are discharged from the hospital. Understanding the epidemiological characteristics of recovered COVID-19 patients who have a re-positive test is vital for preventing a second wave of COVID-19.

methodsThis retrospective study analyzed the epidemiological and clinical features of 20,280 COVID-19 patients from multiple centers in Wuhan who had a positive PCR test between December 31, 2019, and August 4, 2020. The RT-PCR test results for 4079 individuals who had close contact with the re-positive cases were also obtained.

resultsIn total, 2466 (12.16%) of the 20,280 patients had a re-positive SARS-CoV-2 PCR test after they were discharged from the hospital, and 4079 individuals had close contact with members of this patient group. All of these 4079 individuals had a negative SARS-CoV-2 PCR test.

conclusionsThis retrospective study in Wuhan analyzed the basic characteristics of recovered COVID-19 patients with re-positive PCR test and found that these cases may not be infectious.

Indexed as

Disease Transmission, InfectiousAdultChinaCOVID-19COVID-19 TestingFemaleFollow-Up StudiesHumansMaleMiddle AgedPolymerase Chain ReactionRetrospective StudiesSARS-CoV-2Close contactCOVID-19Repeat positiveSubsequent infection

Identifiers

PMID33715626
PMCPMC7956402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.