Evidence map›Paper›PMID 33715445›Full record

ArticleAnnals of clinical biochemistry2021

Personalising laboratory medicine in the 'real world': Assessing clinical utility, by clinical indication, of serum total B

Michael J Murphy, Fiona Brandie, Mildred Ebare, Michelle Harrison, Ellie Dow, William A Bartlett, David Craig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Vitamin BFood & nutrition research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael J MurphyDepartment of Biochemical Medicine, Ninewells Hospital & Medical School, Dundee, UK.ORCID 0000-0001-6735-125X
Fiona BrandieDepartment of Biochemistry, Aberdeen Royal Infirmary, Aberdeen, UK.
Mildred EbareGeneral Practice Training, NHS Education Scotland, Dundee, UK.
Michelle HarrisonDepartment of Haematology, Ninewells Hospital & Medical School, Dundee, UK.
Ellie DowDepartment of Biochemical Medicine, Ninewells Hospital & Medical School, Dundee, UK.
William A BartlettNHS National Services Scotland, Edinburgh, UK.
David CraigAxis Shield Diagnostics Ltd, Dundee, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessing the pre- and post-test probability of disease in the context of routine health care is challenging. We wished to study how test performance parameters relating to clinical utility vary by clinical indication in a 'real-world' setting.

methodsThe diagnostic accuracy of serum total B

resultsClinical indications included peripheral neuropathy (

conclusionCombining diagnostic accuracy studies and electronic testing in a 'real-world' setting allows clinical utility to be assessed by clinical indication. Wider application of this would permit more personalised laboratory medicine. In this study, diagnostic performance of total B

Indexed as

Precision MedicineAdultAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedVitamin B 12Vitamin B 12 DeficiencyBiomarkersVitamin B 12clinical utilitydiagnostic uncertaintyelectronic test requestingEvidence-based medicine‘real-world’ settingvitamin B12Youden cut-offs

Identifiers

PMID33715445
PMCPMC8458683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.