Evidence map›Paper›PMID 33715389›Full record

ArticleOpen biology2021

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner.

Melania Balzarolo, Sander Engels, Anja J de Jong, Katka Franke, Timo K van den Berg, Muhammet F Gulen, Andrea Ablasser, Edith M Janssen, Bas van Steensel, Monika C Wolkers

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. mViruses · 2024
    Review
  5. Review
  6. Epigenetic modifications of DNA and RNA in Alzheimer's disease.Frontiers in molecular neuroscience · 2024
    Review
  7. Review
  8. Article
  9. What nature has to offer: Opportunities for immuno-oncology.Journal of food and drug analysis · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Melania BalzaroloSanquin Research, University of Amsterdam, Amsterdam, The Netherlands.
Sander EngelsSanquin Research, University of Amsterdam, Amsterdam, The Netherlands.
Anja J de JongSanquin Research, University of Amsterdam, Amsterdam, The Netherlands.
Katka FrankeSanquin Research, University of Amsterdam, Amsterdam, The Netherlands.
Timo K van den BergSanquin Research, University of Amsterdam, Amsterdam, The Netherlands.
Muhammet F GulenGlobal Health Institute, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland.
Andrea AblasserGlobal Health Institute, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland.
Edith M JanssenDivision of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, USA.
Bas van SteenselOncode Institute, Utrecht, The Netherlands.
Monika C WolkersSanquin Research, University of Amsterdam, Amsterdam, The Netherlands.
Sanquin · NLÉcole Polytechnique Fédérale de Lausanne · CHCincinnati Children's Hospital Medical Center · USThe Netherlands Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N

Indexed as

DNA MethylationImmunity, InnateAdenineAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteB7-2 AntigenCD69 AntigensCells, CulturedChemokine CXCL10CytoplasmDendritic CellsHumansInterferon-betaLectins, C-TypeMacrophages6-methyladenineAdenineAntigens, CDAntigens, Differentiation, T-LymphocyteB7-2 AntigenCD69 AntigensChemokine CXCL10Interferon-betaLectins, C-TypeNitric Oxide Synthase Type IIOligodeoxyribonucleotidesToll-Like Receptors5′-GATC-3′ motifscGAS–STINGdendritic cellsdouble-stranded (ds)DNAmacrophagesN6-methyl-adenine (m6a)

Identifiers

PMID33715389
PMCPMC8101014
OpenAlexW3133909641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.