Evidence map›Paper›PMID 33715347›Full record

ArticleACS infectious diseases2021

PfMFR3: A Multidrug-Resistant Modulator in

Frances Rocamora, Purva Gupta, Eva S Istvan, Madeline R Luth, Emma F Carpenter, Krittikorn Kümpornsin, Erika Sasaki, Jaeson Calla, Nimisha Mittal, Krypton Carolino and 6 more

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. The Major Facilitator Superfamily Transporter HAP12 Is Critical inInternational journal of molecular sciences · 2025
    Article
  3. Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity toAntimicrobial agents and chemotherapy · 2024
    Article
  4. Comparative chemical genomics inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. iScience · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. PMRT1, amBio · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Frances RocamoraDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States.
Purva GuptaVA San Diego Healthcare System, Medical and Research Sections, La Jolla, California 92161, United States.
Eva S IstvanDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63130, United States.
Madeline R LuthDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States.
Emma F CarpenterWellcome Sanger Institute, Hinxton CB10 1SA, United Kingdom.
Krittikorn KümpornsinWellcome Sanger Institute, Hinxton CB10 1SA, United Kingdom.
Erika SasakiDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States.
Jaeson CallaDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States.
Nimisha MittalDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States.
Krypton CarolinoDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States.
Edward OwenDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Manuel LlinásDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Sabine OttilieDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-9797-2612
Daniel E GoldbergDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63130, United States.ORCID 0000-0003-3529-8399
Marcus C S LeeWellcome Sanger Institute, Hinxton CB10 1SA, United Kingdom.
Elizabeth A WinzelerDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-4049-2113
University of California San Diego · USWellcome Sanger Institute · GBPennsylvania State University · USWashington University in St. Louis · US

Funding

Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Discovery of long-acting, chemoprotective antimalarial compoundsR01AI152533 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2020 to 2024
$3.5M
NIAID NIH HHS R01 AI152533NIGMS NIH HHS T32 GM008666
6 · The paper itself

Abstract

In malaria, chemical genetics is a powerful method for assigning function to uncharacterized genes. MMV085203 and GNF-Pf-3600 are two structurally related napthoquinone phenotypic screening hits that kill both blood- and sexual-stage

Indexed as

AntimalarialsMalariaDrug ResistanceHumansMutationPlasmodium falciparumAntimalarialsdrug discoverydrug resistancemalariamitochondriatransporter

Identifiers

PMID33715347
PMCPMC8042660
OpenAlexW3137386587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.