ArticleJournal of biomedical optics2021
Image-guided Raman spectroscopy probe-tracking for tumor margin delineation.
Article in Journal of biomedical optics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Advancements in Intraoperative Imaging for Enhanced Surgical Precision.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Raman analysis of lipids in cells: Current applications and future prospects.Journal of pharmaceutical analysis · 2025Review
- What's behind Margin Status in Oral Cancer?Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Pixel-level classification of pigmented skin cancer lesions using multispectral autofluorescence lifetime dermoscopy imaging.Biomedical optics express · 2024Article
- Point Projection Mapping System for Tracking, Registering, Labeling, and Validating Optical Tissue Measurements.Journal of imaging · 2024Article
- Intraoperative Assessment of Resection Margin in Oral Cancer: The Potential Role of Spectroscopy.Cancers · 2023Review
- Optical imaging technologies forCurrent opinion in biomedical engineering · 2023Article
- Shedding Light on Colorectal Cancer: An In Vivo Raman Spectroscopy Approach Combined with Deep Learning Analysis.International journal of molecular sciences · 2023Article
- Combining electromyography and Raman spectroscopy: optical EMG.Muscle & nerve · 2023Article
- Optical Tissue Phantoms for Quantitative Evaluation of Surgical Imaging Devices.Advanced photonics research · 2023Article
- Hybrid confocal Raman endomicroscopy for morpho-chemical tissue characterization.Biomedical optics express · 2022Article
- Real-time tracking of a diffuse reflectance spectroscopy probe used to aid histological validation of margin assessment in upper gastrointestinal cancer resection surgery.Journal of biomedical optics · 2022Article
- Review
- A Surgical Pen-Type Probe Design for Real-Time Optical Diagnosis of Tumor Status Using 5-Aminolevulinic Acid.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
significanceTumor detection and margin delineation are essential for successful tumor resection. However, postsurgical positive margin rates remain high for many cancers. Raman spectroscopy has shown promise as a highly accurate clinical spectroscopic diagnostic modality, but its margin delineation capabilities are severely limited by the need for pointwise application.
aimWe aim to extend Raman spectroscopic diagnostics and develop a multimodal computer vision-based diagnostic system capable of both the detection and identification of suspicious lesions and the precise delineation of disease margins. APPROACH: We first apply visual tracking of a Raman spectroscopic probe to achieve real-time tumor margin delineation. We then combine this system with protoporphyrin IX fluorescence imaging to achieve fluorescence-guided Raman spectroscopic margin delineation.
resultsOur system enables real-time Raman spectroscopic tumor margin delineation for both ex vivo human tumor biopsies and an in vivo tumor xenograft mouse model. We then further demonstrate that the addition of protoporphyrin IX fluorescence imaging enables fluorescence-guided Raman spectroscopic margin delineation in a tissue phantom model.
conclusionsOur image-guided Raman spectroscopic probe-tracking system enables tumor margin delineation and is compatible with both white light and fluorescence image guidance, demonstrating the potential for our system to be developed toward clinical tumor resection surgeries.
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