Evidence map›Paper›PMID 33715274›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2021

Eya2 expression during mouse embryonic development revealed by Eya2

Ting Zhang, Jinshu Xu, Pin-Xian Xu

Open access · greenAbstract read
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. A regulatory axis for tonotopic MYO7A expression in cochlear hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ting ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jinshu XuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Pin-Xian XuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-8957-6780
Icahn School of Medicine at Mount Sinai · US

Funding

Transcription factors in kidney developmentR01DK064640 · NIDDK · MC LAUGHLIN RESEARCH INSTITUTE · PI PIN-XIAN XU · 2003 to 2026
$8.9M
Transcriptional networks establishing the precise gene expression states that define neurosensory cell identity in the inner earR01DC014718 · NIDCD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PIN-XIAN XU · 2016 to 2026
$5.2M
NIDCD NIH HHS R01 DC014718NIDDK NIH HHS R01 DK064640
6 · The paper itself

Abstract

backgroundEya2 expression during mouse development has been studied by in situ hybridization and it has been shown to be involved skeletal muscle development and limb formation. Here, we generated Eya2 knockout (Eya2

resultsWe found that Eya2 is expressed in ocular and trochlear motor neurons. In the inner ear, Eya2

conclusionsAs Eya2 is coexpressed with other members of the Eya family genes, these results together highlight that Eya2 as a potential regulator may act synergistically with other Eya genes to regulate the differentiation of the inner ear sensory hair cells and the formation of the salivary gland and thymus.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsCell DifferentiationEar, InnerEmbryonic DevelopmentHearing LossIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutMice, TransgenicNuclear ProteinsProtein Tyrosine PhosphatasesEya2 protein, mouseIntracellular Signaling Peptides and ProteinsNuclear ProteinsProtein Tyrosine Phosphatasescranial placodescranial sensory gangliaEya2hearing lossinner ear hair cellsneural crest cellsocular/trochlear motor neuronssalivary glandsensory organsthymus

Identifiers

PMID33715274
PMCPMC8438093
OpenAlexW3138159092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.