Evidence map›Paper›PMID 33715241›Full record

ArticleEchocardiography (Mount Kisco, N.Y.)2021

Two cases of acute endocarditis misdiagnosed as COVID-19 infection.

Dena E Hayes, David W Rhee, Kazuhiro Hisamoto, Deane Smith, Richard Ro, Alan F Vainrib, Daniel Bamira, Fang Zhou, Muhamed Saric

Abstract readCase Reports
In one paragraph

Article in Echocardiography (Mount Kisco, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. COVID-19-associated MRSA infective endocarditis and mitral valve perforation: a case report.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Bacterial endocarditis masked by COVID-19: A case report.Experimental and therapeutic medicine · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dena E HayesLeon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.ORCID 0000-0003-2386-8163
David W RheeLeon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.
Kazuhiro HisamotoDepartment of Cardiothoracic Surgery, New York University Langone Health, New York, NY, USA.
Deane SmithDepartment of Cardiothoracic Surgery, New York University Langone Health, New York, NY, USA.
Richard RoLeon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.
Alan F VainribLeon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.
Daniel BamiraLeon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.
Fang ZhouDepartment of Pathology, New York University Langone Health, New York, NY, USA.
Muhamed SaricLeon H. Charney Division of Cardiology, New York University Langone Health, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has presented countless new challenges for healthcare providers including the challenge of differentiating COVID-19 infection from other diseases. COVID-19 infection and acute endocarditis may present similarly, both with shortness of breath and vital sign abnormalities, yet they require very different treatments. Here, we present two cases in which life-threatening acute endocarditis was initially misdiagnosed as COVID-19 infection during the height of the pandemic in New York City. The first was a case of Klebsiella pneumoniae mitral valve endocarditis leading to papillary muscle rupture and severe mitral regurgitation, and the second a case of Streptococcus mitis aortic valve endocarditis with heart failure due to severe aortic regurgitation. These cases highlight the importance of careful clinical reasoning and demonstrate how cognitive errors may impact clinical reasoning. They also underscore the limitations of real-time reverse transcription-polymerase chain reaction (RT-PCR) for SARS-CoV-2 testing and illustrate the ways in which difficulty interpreting results may also influence clinical reasoning. Accurate diagnosis of acute endocarditis is critical given that surgical intervention can be lifesaving in unstable patients.

Indexed as

COVID-19EndocarditisEndocarditis, BacterialHeart Valve ProsthesisAortic ValveCOVID-19 TestingDiagnostic ErrorsHumansPandemicsSARS-CoV-2bioprosthesisCOVID-19endocarditismisdiagnosisvalve replacement

Identifiers

PMID33715241
PMCPMC8251260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.