Evidence map›Paper›PMID 33715111›Full record

ArticleInflammation2021

Lung Edema and Mortality Induced by Intestinal Ischemia and Reperfusion Is Regulated by VAChT Levels in Female Mice.

Fernanda P R Santana, Fernanda Y Ricardo-da-Silva, Evelyn T Fantozzi, Nathália M Pinheiro, Iolanda F L C Tibério, Luiz Felipe Pinho Moreira, Marco Antônio M Prado, Vânia F Prado, Wothan Tavares-de-Lima, Carla Máximo Prado and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fernanda P R SantanaDepartment of Biological Science, Federal University of São Paulo, Diadema, Brazil.
Fernanda Y Ricardo-da-SilvaLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Evelyn T FantozziDepartment of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Nathália M PinheiroDepartment of Bioscience, Federal University of São Paulo, Campus Baixada Santista, Rua Silva Jardim, 136 - Vila Mathias, Santos, SP, Brazil.
Iolanda F L C TibérioDepartment of Internal Medicine, School of Medicine, University of São Paulo, São Paulo, Brazil.
Luiz Felipe Pinho MoreiraLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Marco Antônio M PradoRobarts Research Institute, Department of Physiology & Pharmacology, The University of Western Ontario, London, Canada.
Vânia F PradoRobarts Research Institute, Department of Physiology & Pharmacology, The University of Western Ontario, London, Canada.
Wothan Tavares-de-LimaDepartment of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Carla Máximo PradoDepartment of Biological Science, Federal University of São Paulo, Diadema, Brazil. carla.prado@unifesp.br.ORCID http://orcid.org/0000-0003-1160-0442
Ana Cristina Breithaupt-FaloppaLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 306278/2015-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/25689-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/06088-0
6 · The paper itself

Abstract

Acute lung injury induced by intestinal ischemia/reperfusion (I/R) is a relevant clinical condition. Acetylcholine (ACh) and the α7 nicotinic ACh receptor (nAChRα-7) are involved in the control of inflammation. Mice with reduced levels of the vesicular ACh transporter (VAChT), a protein responsible for controlling ACh release, were used to test the involvement of cholinergic signaling in lung inflammation due to intestinal I/R. Female mice with reduced levels of VAChT (VAChT-KD

Indexed as

AnimalsFemaleInflammation MediatorsIntestinesMiceMice, TransgenicOvariectomyPulmonary EdemaReperfusion InjuryVesicular Acetylcholine Transport ProteinsInflammation MediatorsSlc18a3 protein, mouseVesicular Acetylcholine Transport Proteinsacetylcholineacute lung injurycholinergic anti-inflammatory pathwayexperimental modelintestinal ischemia and reperfusionPNU-282,987

Identifiers

PMID33715111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.