ArticleAging2021
Nutrition status mediates the association between cognitive decline and sarcopenia.
Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study.PloS one · 2024Pooled it
- A nomogram model for identifying cognitive frailty in elderly patients with chronic diseases: a multicenter cross-sectional study.Frontiers in public health · 2026Observational
- Association between oropharyngeal dysphagia and functional constipation in older adults: a cross-sectional study.Frontiers in public health · 2026Article
- Associations of Nutritional Health Risk With Cognitive Function in Older Korean Adults: The Mediating Roles of Lower Body Strength and Depression.Geriatrics & gerontology international · 2025Article
- Associations Between Poor Appetite, Sarcopenia, and Cognitive Function in Community-dwelling Malaysian Older Adults.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- New indicators related to the osteosarcopenia in the elderly: assessment of intrinsic capacity.BMC geriatrics · 2025Article
- Association between sarcopenia and falls, fractures, hospital readmission, and all-cause mortality in older adults with endocrine disorders: a longitudinal study of aging in China.BMC musculoskeletal disorders · 2025Article
- Explaining the Association Between Number of Teeth and Frailty in Older Chinese Adults: The Chain Mediating Effect of Nutritional Status and Cognitive Function.International journal of nursing practice · 2025Article
- Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes.Frontiers in aging neuroscience · 2025Article
- Article
- Association between Intrinsic Capacity and Sarcopenia in Hospitalized Older Patients.The journal of nutrition, health & aging · 2023Article
- Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link.Nutrients · 2022Article
- Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated whether nutrition status mediates the relationship between cognitive decline and sarcopenia. Sarcopenia was assessed in 4023 community-dwelling older adults from West China using the AWGS 2014 diagnostic criteria. Cognitive function and nutrition status were assessed using the 10-item Short Portable Mental Status Questionnaire (SPMSQ) and Mini Nutrition Assessment-Short Form (MNA-SF) scale, respectively. Mediation model regression analysis demonstrated that nutrition status was negatively associated with sarcopenia (β = -0.521; 95% CI: -0.583 to -0.459). The indirect effects of cognitive decline on sarcopenia were significant after adjusting for age, sex, and ethnicity (β = 0.015; 95% CI: 0.012 to 0.017), but the direct effects of cognitive decline on sarcopenia were not statistically significant after adding nutrition status as a parameter in the mediation model analysis (β = -0.001; 95% CI: -0.008 to 0.005). Structural equation model (SEM) framework pathway analysis confirmed the association between nutrition status, cognitive decline, and sarcopenia. These findings demonstrate that the negative effects of cognitive decline on sarcopenia were mediated by nutrition status. We therefore postulate that maintaining a good nutrition status delays the negative effects of cognitive decline on sarcopenia in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.