ArticleSeminars in cell & developmental biology2021
Developmental regulation of excitatory-inhibitory synaptic balance in the prefrontal cortex during adolescence.
Article in Seminars in cell & developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- A Meta-Analysis of Magnetic Resonance Spectroscopy Studies on Glutamatergic Neurometabolite Levels in Major Depressive Disorder.Depression and anxiety · 2025Pooled it
- Childhood adversity and psychotic-like experiences in adolescence: Investigating a pathway via disrupted pubertal and grey matter development.JCPP advances · 2026Article
- Neuromodulatory roles of the sigma-1 receptor in behavior and drug sensitization during development.Acta pharmacologica Sinica · 2026Article
- The Associations of Grey Matter Thickness and White Matter Parameters on Corticospinal Excitability in Adolescence: A Navigated TMS Study.Brain topography · 2026Article
- The impact of pregestational stress on neurodevelopment: Implications for autism spectrum disorder and attention-deficit/hyperactivity disorder.The Journal of physiology · 2026Review
- Adolescent cannabinoid exposure delays development of prefrontal cortex perineuronal nets and inhibitory interneurons.Neuroscience · 2026Article
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- Aperiodic Signatures of Stress Sensitivity and Depression Recurrence in Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Developmental trajectories of glutamate and the variable clinical course of ADHD in youth.Translational psychiatry · 2026Article
- Adolescent and adult stress alter excitatory-inhibitory network dynamics in the medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neurodevelopmental considerations for transcranial magnetic stimulation trials in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neurobehavioral correlates of inhibitory control in youth at-risk for early low-level alcohol use initiation: neuroimaging findings from the ABCD study.Frontiers in psychiatry · 2026Article
- From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.Frontiers in cell and developmental biology · 2026Review
- Cross-species evidence for the refinement of intrinsic neural timescales supporting executive system maturation through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Cerebral glutamate levels over two years in initially antipsychotic-naïve first-episode patients with psychosis are related to clinical symptoms and cognition.Molecular psychiatry · 2025Article
- Clozapine induces perineuronal net remodeling in a developmental mouse model exhibiting schizophrenia-relevant phenotypes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior.Neurobiology of stress · 2025Article
- Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics.Nature communications · 2025Article
- Cannabinoid CB1 receptor-sensitive neurodevelopmental processes and trajectories.Molecular psychiatry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The prefrontal cortex (PFC) is a cortical structure involved in a variety of complex functions in the cognitive and affective domains. The intrinsic function of the PFC is defined by the interaction of local glutamatergic and GABAergic neurons and their modulation by long-range inputs. The ensuing interactions generate a ratio of excitation and inhibition (E-I) in each output neuron, a balance which is refined during the adolescent to adult transition. In this short review, we aim to describe how an increase in GABAergic transmission during adolescence modifies the E-I ratio in adults. We further discuss how this new setpoint may change the dynamics of PFC networks observed during the transition to adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.