ReviewMayo Clinic proceedings2021
The Oxygen Cascade During Exercise in Health and Disease.
Review in Mayo Clinic proceedings, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- The impact of breathing route on pulmonary and sensory responses to ozone exposure during exercise in adults.Physiological reports · 2026Trial
- Lifelong hypoxia produces multigenerational developmental lung disease and pulmonary hypertension in mice.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- The Impact of Additional Respiratory Dead Space Volume Mask During Warm-Up on Skin Blood Flow and Choice Reaction Time in Cyclists: A Randomized Crossover Trial.Journal of clinical medicine · 2026Article
- One half of the sprinting coin: the oxygen transport cascade of a 91-yr-old female world-record sprinter.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- A comparison of the neuromuscular, cardiopulmonary and muscle oxygenation responses to single- and double-leg cycling in older adults.Experimental physiology · 2026Article
- Near-Infrared Spectroscopy in the Pathophysiology, Diagnosis, and Exercise-Based Management of Muscle Oxygenation Impairment.Diagnostics (Basel, Switzerland) · 2026Review
- Exercise in Hypoxic Environments: An Overview of Systematic Reviews on Performance, Physiological Adaptation, and Clinical Implications.Sports (Basel, Switzerland) · 2026Review
- The Influence of Menstrual Cycle Phase on the Physiological and Perceptual Responses to Low-Intensity Continuous and High-Intensity Interval Sessions in Endurance Trained Women: The FENDURA Project.European journal of sport science · 2026Article
- Exercise Pulmonary Hypertension and Beyond: Insights in Exercise Pathophysiology in Pulmonary Arterial Hypertension (PAH) from Invasive Cardiopulmonary Exercise Testing.Journal of clinical medicine · 2025Review
- Computer model coupling hemodynamics and oxygen transport in the coronary capillary network: Pulsatile vs. non-pulsatile analysis.Computer methods and programs in biomedicine · 2025Article
- Article
- Identifying limitations to exercise with incremental cardiopulmonary exercise testing: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024Article
- Assessment of hypoxemia among young adults with sickle cell anaemia in steady state in southwestern Nigeria: a crosssectional study.BMC research notes · 2024Article
- Alternative blood transfusion triggers: a narrative review.BMC anesthesiology · 2024Review
- Women at Altitude: Sex-Related Physiological Responses to Exercise in Hypoxia.Sports medicine (Auckland, N.Z.) · 2024Review
- Exercise and Experiments of Nature.Comprehensive Physiology · 2023Article
- The Oxygen Cascade from Atmosphere to Mitochondria as a Tool to Understand the (Mal)adaptation to Hypoxia.International journal of molecular sciences · 2023Review
- Usefulness of pyruvate dehydrogenase-E1α expression to determine SUVmax cut-off value of [Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The oxygen transport cascade describes the physiological steps that bring atmospheric oxygen into the body where it is delivered and consumed by metabolically active tissue. As such, the oxygen cascade is fundamental to our understanding of exercise in health and disease. Our narrative review will highlight each step of the oxygen transport cascade from inspiration of atmospheric oxygen down to mitochondrial consumption in both healthy active males and females along with clinical conditions. We will focus on how different steps interact along with principles of homeostasis, physiological redundancies, and adaptation. In particular, we highlight some of the parallels between elite athletes and clinical conditions in terms of the oxygen cascade.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.