Evidence map›Paper›PMID 33714219›Full record

ArticleClinical and experimental immunology2021

The frequency of interleukin-1β-producing monocytes is significantly associated with varicella-zoster responses of nursing home residents.

E Picard, D M E Bowdish, J E McElhaney, G Pawelec, M Loeb, C P Verschoor

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Biological relevance ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

E PicardHealth Sciences North Research Institute, Sudbury, ON, Canada.ORCID 0000-0002-8104-1554
D M E BowdishDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
J E McElhaneyHealth Sciences North Research Institute, Sudbury, ON, Canada.
G PawelecHealth Sciences North Research Institute, Sudbury, ON, Canada.
M LoebDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
C P VerschoorHealth Sciences North Research Institute, Sudbury, ON, Canada.
Health Sciences North · CAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have demonstrated that the status of the T cell compartment and inflammation-related factors are associated with the immunogenicity of the varicella-zoster virus (VZV) vaccine in older adults; however, little is known about the roles of other immune cell subsets known to influence the generation and maintenance of immunological memory. Responses to a live-attenuated VZV vaccine were studied in relation to peripheral blood mononuclear cell (PBMC) composition and function in a sample of 30 nursing home residents (aged 80-99 years). Interferon-gamma enzyme-linked immunospot (ELISPOT) was used to measure VZV responses at baseline and 6 weeks following vaccination, and associations were sought with the frequencies of monocytes and T, B and natural killer (NK) cells and the production and secretion of cytokines following their ex-vivo stimulation with different agents. While only the frequency of interleukin (IL)-6

Indexed as

Aged, 80 and overB-LymphocytesCytokinesFemaleHerpesvirus 3, HumanHerpes ZosterHumansImmunologic MemoryInflammationInterleukin-1betaKiller Cells, NaturalLeukocytes, MononuclearMaleMonocytesNursing HomesT-LymphocytesCytokinesIL1B protein, humanInterleukin-1betaVaccines, AttenuatedIL-1βinflammationinflammatory monocytesmemory T cell maintenancevaricella zoster virus

Identifiers

PMID33714219
PMCPMC8209608
OpenAlexW3135960784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.