Evidence map›Paper›PMID 33714076›Full record

SynthesisJournal of psychiatric research2021

Estimating the risk of suicide associated with mental disorders: A systematic review and meta-regression analysis.

Modhurima Moitra, Damian Santomauro, Louisa Degenhardt, Pamela Y Collins, Harvey Whiteford, Theo Vos, Alize Ferrari

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 12 pooled it
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 12 syntheses or guidelines pooled it, 228 citations in OpenAlex.

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  3. Suicidal Ideation, Behaviors, and Deaths in People With Ménière's Disease: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Modhurima MoitraInstitute for Health Metrics and Evaluation, University of Washington, United States; Department of Global Health, University of Washington, United States. Electronic address: moitra@uw.edu.
Damian SantomauroInstitute for Health Metrics and Evaluation, University of Washington, United States; The University of Queensland, School of Public Health, Queensland, Australia; Queensland Centre for Mental Health Research, Queensland, Australia.
Louisa DegenhardtInstitute for Health Metrics and Evaluation, University of Washington, United States; National Drug and Alcohol Research Center, University of New South Wales, Australia.
Pamela Y CollinsDepartment of Global Health, University of Washington, United States; Department of Psychiatry and Behavioral Sciences, University of Washington, United States.
Harvey WhitefordInstitute for Health Metrics and Evaluation, University of Washington, United States; The University of Queensland, School of Public Health, Queensland, Australia; Queensland Centre for Mental Health Research, Queensland, Australia.
Theo VosInstitute for Health Metrics and Evaluation, University of Washington, United States.
Alize FerrariInstitute for Health Metrics and Evaluation, University of Washington, United States; The University of Queensland, School of Public Health, Queensland, Australia; Queensland Centre for Mental Health Research, Queensland, Australia.
University of Washington · USQueensland Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMental disorders (MDs) are known risk factors for suicide. This systematic review updates the evidence base for this association and improves upon analytic approaches by incorporating study-level and methodological variables to account for measurement error in pooled suicide risk estimates.

methodsA systematic review was conducted to review studies on MDs as risk factors for suicide. Relevant studies were searched using PubMed, Embase, PsychINFO, and existing reviews from 2010 to 19. Studies were eligible if they were longitudinal/case-control studies, representative of the general population, used diagnostic instruments, and quantified suicide risk. The outcome assessed was relative risks (RRs) for suicide due to MDs. A multi-level meta-regression approach was used to obtain pooled RRs adjusted for covariates and between-study effects.

findingsWe identified 20 eligible studies yielding 69 RRs. Disorder type, age, sex, use of psychological autopsy, study design, and adjustment for confounders were tested as predictors of pooled suicide risk. Overall, all disorders were significant predictors of suicide with predicted adjusted RRs ranging from 4·11 [2·09, 8·09] for dysthymia to 7·64 [4·3, 13·58] for major depressive disorder.

interpretationOur results indicate that MDs are important risk factors for suicide. This systematic review provides pooled RRs that have been adjusted for methodological sources of bias. Findings from our paper may inform suicide prevention strategies as part of national health agendas.

Indexed as

Major Depressive DisorderMental DisordersSuicideCase-Control StudiesHumansRegression AnalysisRisk FactorsGlobal mental healthMental disordersMeta-regressionSuicideSystematic review

Identifiers

PMID33714076
PMCPMC8095367
OpenAlexW3133660108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.