Evidence map›Paper›PMID 33713889›Full record

ArticleEpilepsy research2021

Delineation of epileptogenic zones with high frequency magnetic source imaging based on kurtosis and skewness.

Jing Xiang, Ellen Maue, Hisako Fujiwara, Francesco T Mangano, Hansel Greiner, Jeffrey Tenney

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00600717 (Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00600717 withdrawnnot on this map

Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2000 to 2027Enrolled0ConditionsEpilepsy, Migraine, Headache, Pain
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing XiangMEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Jing.xiang@cchmc.org.
Ellen MaueMEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hisako FujiwaraDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Francesco T ManganoDivision of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hansel GreinerDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jeffrey TenneyMEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Funding

Neuromagnetic High Frequency Oscillations to Guide Epilepsy SurgeryR21NS104459 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI XIANG, JING · 2018 to 2019
$414k
Aberrant Neuromagnetic Signatures with Chronic MigraineR21NS081420 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI XIANG, JING · 2013 to 2014
$398k
Motor cortex dysfunction in migraineR21NS072817 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI XIANG, JING · 2010 to 2011
$356k
NINDS NIH HHS R21 NS072817NINDS NIH HHS R21 NS081420NINDS NIH HHS R21 NS104459
6 · The paper itself

Abstract

backgroundNeuromagnetic high frequency brain signals (HFBS, > 80 Hz) are a new biomarker for localization of epileptogenic zones (EZs) for pediatric epilepsy.

methodsTwenty three children with drug-resistant epilepsy and age/sex matched healthy controls were studied with magnetoencephalography (MEG). Epileptic HFBS in 80-250 Hz and 250-600 Hz were quantitatively determined by comparing with normative controls in terms of kurtosis and skewness. Magnetic sources of epileptic HFBS were localized and then compared to clinical EZs determined by invasive recordings and surgical outcomes.

resultsKurtosis and skewness of HFBS were significantly elevated in epilepsy patients compared to healthy controls (p < 0,001 and p < 0.0001, respectively). Sources of elevated MEG signals in comparison to normative data were co-localized to EZs for 22 (22/23, 96 %) patients.

conclusionsThe results indicate, for the first time, that epileptic HFBS can be noninvasively quantified by measuring kurtosis and skewness in MEG data. Magnetic source imaging based on kurtosis and skewness can accurately localize EZs. SIGNIFICANCE: Source imaging of kurtosis and skewness of MEG HFBS provides a novel way for preoperative localization of EZs for epilepsy surgery.

Indexed as

Drug Resistant EpilepsyEpilepsyBrainChildElectroencephalographyHumansMagnetic PhenomenaMagnetic Resonance ImagingMagnetoencephalographyEpilepsyHigh frequency brain signalsKurtosisMagnetic source imagingMagnetoencephalographySkewness

Identifiers

PMID33713889
PMCPMC8052290

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.