ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2021
Quantitative and Qualitative Sex Modulations in the Brain Anatomy of Autism.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Sex differences in trajectories of cortical development in autistic children from 2-13 years of age.Molecular psychiatry · 2024Article
- Dataset factors associated with age-related changes in brain structure and function in neurodevelopmental conditions.Human brain mapping · 2024Article
- Structural Brain Imaging Biomarkers of Autism Spectrum Disorder.Advances in neurobiology · 2024Review
- Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.medRxiv : the preprint server for health sciences · 2023Article
- Sex and gender in neurodevelopmental conditions.Nature reviews. Neurology · 2023Review
- Unique dynamic profiles of social attention in autistic females.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Sex-dependent structure of socioemotional salience, executive control, and default mode networks in preschool-aged children with autism.NeuroImage · 2022Article
- Altered Development of Amygdala-Connected Brain Regions in Males and Females with Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Deep learning identifies robust gender differences in functional brain organization and their dissociable links to clinical symptoms in autism.The British journal of psychiatry : the journal of mental science · 2022Article
- Differences in Degree and Form.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundSex-based neurobiological heterogeneity in autism is poorly understood. Research is disproportionately biased to males, leading to an unwarranted presumption that autism neurobiology is the same across sexes. Previous neuroimaging studies using amalgamated multicenter datasets to increase autistic female samples are characterized by large statistical noise.
methodsWe used a better-powered dataset of 1183 scans of 839 individuals-299 (467 scans) autistic males, 74 (102 scans) autistic females, 240 (334 scans) control males, and 226 (280 scans) control females-to test two whole-brain models of overall/global sex modulations on autism neuroanatomy, by summary measures computed across the brain: the local magnitude model, in which the same brain regions/circuitries are involved across sexes but effect sizes are larger in females, indicating quantitative sex modulation; and spatial dissimilarity model, in which the neuroanatomy differs spatially between sexes, indicating qualitative sex modulation. The male and female autism groups were matched on age, IQ, and autism symptoms. Autism brain features were defined by comparisons with same-sex control individuals.
resultsAcross five metrics (cortical thickness, surface area, volume, mean absolute curvature, and subcortical volume), we found no evidence supporting the local magnitude model. We found indicators supporting the spatial dissimilarity model on cortical mean absolute curvature and subcortical volume, but not on other metrics.
conclusionsThe overall/global autism neuroanatomy in females and males does not simply differ quantitatively in the same brain regions/circuitries. They may differ qualitatively in spatial involvement in cortical curvature and subcortical volume. The neuroanatomy of autism may be partly sex specific. Sex stratification to inform autism preclinical/clinical research is needed to identify sex-informed neurodevelopmental targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.