Evidence map›Paper›PMID 33713831›Full record

ArticleSeminars in thoracic and cardiovascular surgery2022

Two Hours of In Vivo Lung Perfusion Improves Lung Function in Sepsis-Induced Acute Respiratory Distress Syndrome.

Matthew R Byler, Nathan S Haywood, Dustin T Money, Aimee Zhang, Jared P Beller, Eric J Charles, William Z Chancellor, Huy Q Ta, Mark H Stoler, J Hunter Mehaffey and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seminars in thoracic and cardiovascular surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Matthew R BylerDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Nathan S HaywoodDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Dustin T MoneyDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Aimee ZhangDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Jared P BellerDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Eric J CharlesDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
William Z ChancellorDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Huy Q TaDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Mark H StolerDepartment of Pathology, University of Virginia, Charlottesville, Virginia.
J Hunter MehaffeyDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Victor E LaubachDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Irving L KronDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Mark E RoeserDepartment of Surgery, University of Virginia, Charlottesville, Virginia. Electronic address: mr8be@virginia.edu.
University of Virginia · US

Funding

Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
In Vivo Lung Perfusion for the Surgical Treatment of Acute Respiratory Distress SyndromeR01HL142110 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRON, IRVING L., LAUBACH, VICTOR E · 2018 to 2021
$2.3M
The Next Step: Regadenoson mitigates ischemia reperfusion injury and is renal protective in a 48 hour porcine model of resuscitative ECMOK08HL146995 · NHLBI · UNIVERSITY OF VIRGINIA · PI ROESER, MARK · 2019 to 2023
$827k
NHLBI NIH HHS K08 HL146995NHLBI NIH HHS R01 HL142110NHLBI NIH HHS T32 HL007849
6 · The paper itself

Abstract

Sepsis is the leading cause of acute respiratory distress syndrome (ARDS) in adults and carries a high mortality. Utilizing a previously validated porcine model of sepsis-induced ARDS, we sought to refine our novel therapeutic technique of in vivo lung perfusion (IVLP). We hypothesized that 2 hours of IVLP would provide non-inferior lung rehabilitation compared to 4 hours of treatment. Adult swine (n = 8) received lipopolysaccharide to develop ARDS and were placed on central venoarterial extracorporeal membrane oxygenation. Animals were randomized to 2 vs 4 hours of IVLP. The left pulmonary vessels were cannulated to IVLP using antegrade Steen solution. After IVLP treatment, the left lung was decannulated and reperfused for 4 hours. Total lung compliance and pulmonary venous gases from the right lung (control) and left lung (treatment) were sampled hourly. Biochemical analysis of tissue and bronchioalveolar lavage was performed along with tissue histologic assessment. Throughout IVLP and reperfusion, treated left lung PaO

Indexed as

Respiratory Distress SyndromeSepsisAnimalsExtracorporeal Membrane OxygenationLungPerfusionPharmaceutical SolutionsSwineTreatment OutcomePharmaceutical SolutionsAcute lung injuryIn vivo lung perfusionLung rehabilitation

Identifiers

PMID33713831
PMCPMC8433279
OpenAlexW3134089874

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.