Evidence map›Paper›PMID 33713765›Full record

ArticleThe Journal of allergy and clinical immunology2021

The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities.

Christina D Chambers, Jerry A Krishnan, Lorene Alba, Jessica D Albano, Allison S Bryant, Melanie Carver, Lee S Cohen, Elena Gorodetsky, Sonia Hernandez-Diaz, Margaret A Honein and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Medication use during pregnancy in Japan from 2005 to 2019: Trends and safety considerations.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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  7. International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: Physician perspectives.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Article
  8. Lower Adherence to Breastfeeding Recommendations in Mothers Treated With Antirheumatic and Antidepressant Medications.Journal of human lactation : official journal of International Lactation Consultant Association · 2025
    Article
  9. Article
  10. Asthma and pregnancy.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Review
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  13. Observational
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  17. Asthma and pregnancy.Revista da Associacao Medica Brasileira (1992) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 1 country.

Christina D ChambersDepartment of Pediatrics, University of California, San Diego, La Jolla, Calif. Electronic address: chchambers@health.ucsd.edu.
Jerry A KrishnanUniversity of Illinois at Chicago, Chicago, Ill.
Lorene AlbaAsthma and Allergy Foundation of America, Arlington, Va.
Jessica D AlbanoSyneos Health, Morrisville, NC.
Allison S BryantMassachusetts General Hospital, Boston, Mass.
Melanie CarverAsthma and Allergy Foundation of America, Arlington, Va.
Lee S CohenMassachusetts General Hospital, Boston, Mass.
Elena GorodetskyOffice of Research on Women's Health, Bethesda, Md.
Sonia Hernandez-DiazHarvard T.H. Chan School of Public Health, Boston, Mass.
Margaret A HoneinUS Centers for Disease Control and Prevention, Atlanta, Ga.
Bridgette L JonesChildren's Mercy Kansas City, Kansas City, Mo; University of Missouri Kansas City School of Medicine, Children's Mercy Kansas City, Kansas City, Mo.
Richard K MurrayAsthma and Allergy Foundation of America, Arlington, Va.
Jennifer A NamazySCRIPPS CLINIC, San Diego, Calif.
Leyla SahinUS Food and Drug Administration, Silver Spring, Md.
Catherine Y Spongthe Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Tex.
Kaveeta P VasishtUS Food and Drug Administration, Office of Women's Health, Silver Spring, Md.
Kevin WattUniversity of Utah School of Medicine, Salt Lake City, Utah.
Keele E WurstGlaxoSmithKline, Research Triangle Park, NC.
Lynne YaoSCRIPPS CLINIC, San Diego, Calif.
Michael SchatzKaiser Permanente Medical Center, San Diego, Calif.
Asthma and Allergy Foundation of America · USMassachusetts General Hospital · USScripps Clinic · USUnited States Food and Drug Administration · USChildren's Mercy Hospital · USGlaxoSmithKline (United States) · USHarvard University · USKaiser Permanente San Diego Medical Center · USSouthwestern Medical CenterSyneos Health (United States) · USUniversity of California, San Diego · USUniversity of Illinois Chicago · USUniversity of Utah · US

Funding

Understanding Mechanisms Underlying Chronic Stress-Induced Asthma in Children by Population and Single-Cell Epigenomics ApproachesR01MD015409 · NIMHD · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI GRUNDBERG, ELIN · 2020 to 2024
$3.6M
A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric AsthmaR01HD100545 · NICHD · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI JONES, BRIDGETTE L. · 2020 to 2024
$2.5M
The Safety of Asthma Medications During Pregnancy and Lactation: Evidence Gaps and How to Fill ThemR13HL149440 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAMBERS, CHRISTINA · 2019 to 2019
$20k
NHLBI NIH HHS R13 HL149440NICHD NIH HHS R01 HD100545NIMHD NIH HHS R01 MD015409
6 · The paper itself

Abstract

Asthma is one of the most common underlying diseases in women of reproductive age that can lead to potentially serious medical problems during pregnancy and lactation. A group of key stakeholders across multiple relevant disciplines was invited to take part in an effort to prioritize, strategize, and mobilize action steps to fill important gaps in knowledge regarding asthma medication safety in pregnancy and lactation. The stakeholders identified substantial gaps in the literature on the safety of asthma medications used during pregnancy and lactation and prioritized strategies to fill those gaps. Short-term action steps included linking data from existing complementary study designs (US and international claims data, single drug pregnancy registries, case-control studies, and coordinated systematic data systems). Long-term action steps included creating an asthma disease registry, incorporating the disease registry into electronic health record systems, and coordinating care across disciplines. The stakeholders also prioritized establishing new infrastructures/collaborations to perform research in pregnant and lactating women and to include patient perspectives throughout the process. To address the evidence gaps, and aid in populating product labels with data that inform clinical decision making, the consortium developed a plan to systematically obtain necessary data in the most efficient and timely manner.

Indexed as

LactationAsthmaBreast FeedingCase-Control StudiesClinical Decision-MakingDisease ManagementFemaleHumansPregnancyPregnancy ComplicationsRegistriesResearchResearch DesignAsthma medicationlactationpregnancy

Identifiers

PMID33713765
PMCPMC8185876
OpenAlexW3133906055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.