Evidence map›Paper›PMID 33713650›Full record

ArticleInternational journal for parasitology2021

Genetic and biological characterisation of three cryptic Eimeria operational taxonomic units that infect chickens (Gallus gallus domesticus).

Damer P Blake, Vladimir Vrba, Dong Xia, Isa Danladi Jatau, Simon Spiro, Matthew J Nolan, Greg Underwood, Fiona M Tomley

Abstract read
In one paragraph

Article in International journal for parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
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  3. Microorganisms · 2026
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  5. Genetic diversity inVeterinary world · 2026
    Review
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  7. Article
  8. UnderstandingFrontiers in cellular and infection microbiology · 2026
    Review
  9. NGS‑based characterization of Eimeria spp. prevalence and diversity in broiler farms in northwestern São Paulo State, Brazil.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026
    Article
  10. Exploring the interplay betweenThe veterinary quarterly · 2025
    Review
  11. Article
  12. Simultaneous Detection and Differentiation of FourAnimals : an open access journal from MDPI · 2025
    Article
  13. Article
  14. Novel organoids andParasitology · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Damer P BlakePathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms AL9 7TA, UK. Electronic address: dblake@rvc.ac.uk.
Vladimir VrbaBioproperties Pty Ltd, 36 Charter St, Ringwood, Victoria 3134, Australia.
Dong XiaPathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms AL9 7TA, UK.
Isa Danladi JatauDepartment of Parasitology and Entomology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
Simon SpiroWildlife Health Services, Zoological Society of London, Regent's Park, London NW1 4RY, UK.
Matthew J NolanPathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms AL9 7TA, UK.
Greg UnderwoodBioproperties Pty Ltd, 36 Charter St, Ringwood, Victoria 3134, Australia.
Fiona M TomleyPathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms AL9 7TA, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/H009337/1Biotechnology and Biological Sciences Research Council BB/L00478X/1
6 · The paper itself

Abstract

More than 68 billion chickens were produced globally in 2018, emphasising their major contribution to the production of protein for human consumption and the importance of their pathogens. Protozoan Eimeria spp. are the most economically significant parasites of chickens, incurring global costs of more than UK £10.4 billion per annum. Seven Eimeria spp. have long been recognised to infect chickens, with three additional cryptic operational taxonomic units (OTUs) first described more than 10 years ago. As the world's farmers attempt to reduce reliance on routine use of antimicrobials in livestock production, replacing drugs that target a wide range of microbes with precise species- and sometimes strain-specific vaccines, the breakthrough of cryptic genetic types can pose serious problems. Consideration of biological characteristics including oocyst morphology, pathology caused during infection and pre-patent periods, combined with gene-coding sequences predicted from draft genome sequence assemblies, suggest that all three of these cryptic Eimeria OTUs possess sufficient genetic and biological diversity to be considered as new and distinct species. The ability of these OTUs to compromise chicken bodyweight gain and escape immunity induced by current commercially available anticoccidial vaccines indicates that they could pose a notable threat to chicken health, welfare, and productivity. We suggest the names Eimeria lata n. sp., Eimeria nagambie n. sp. and Eimeria zaria n. sp. for OTUs x, y and z, respectively, reflecting their appearance (x) or the origins of the first isolates of these novel species (y, z).

Indexed as

CoccidiosisEimeriaPoultry DiseasesProtozoan VaccinesAnimalsChickensHumansNigeriaProtozoan VaccinesChickensCryptic speciesEimeriaFood securityGenome sequencingOperational taxonomic unit

Identifiers

PMID33713650
PMCPMC8186487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.