ArticleBiochemical pharmacology2021
Diazepam effects on local cortical neural activity during sleep in mice.
Article in Biochemical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
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- Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications.Annals of medicine · 2025Review
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- Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus.Epilepsia · 2025Article
- The effects of diazepam on sleep depend on the photoperiod.Acta pharmacologica Sinica · 2025Article
- Dynamic changes in sleep architecture in a mouse model of acute kidney injury transitioning to chronic kidney disease.Frontiers in neuroscience · 2025Article
- Heukharang (Sleep and biological rhythms · 2024Article
- A longitudinal electrophysiological and behavior dataset for PD rat in response to deep brain stimulation.Scientific data · 2024Article
- Feasibility of applying a noninvasive method for sleep monitoring based on mouse behaviors.Brain and behavior · 2023Article
- Quercetin Antagonizes the Sedative Effects of Linalool, Possibly through the GABAergic Interaction Pathway.Molecules (Basel, Switzerland) · 2023Article
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- The GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Detection of neuronal OFF periods as low amplitude neural activity segments.BMC neuroscience · 2023Article
- The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders.Advances in neurobiology · 2023Article
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- Difference in spectral power density of sleep electroencephalography between individuals without insomnia and frequent hypnotic users with insomnia complaints.Scientific reports · 2022Article
- Neuroprotective effect of Ziziphi Spinosae Semen on rats with p-chlorophenylalanine-induced insomniaFrontiers in pharmacology · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
GABA-ergic neurotransmission plays a key role in sleep regulatory mechanisms and in brain oscillations during sleep. Benzodiazepines such as diazepam are known to induce sedation and promote sleep, however, EEG spectral power in slow frequencies is typically reduced after the administration of benzodiazepines or similar compounds. EEG slow waves arise from a synchronous alternation between periods of cortical network activity (ON) and silence (OFF), and represent a sensitive marker of preceding sleep-wake history. Yet it remains unclear how benzodiazepines act on cortical neural activity during sleep. To address this, we obtained chronic recordings of local field potentials and multiunit activity (MUA) from deep cortical layers of the primary motor cortex in freely behaving mice after diazepam injection. We found that the amplitude of individual LFP slow waves was significantly reduced after diazepam injection and was accompanied by a lower incidence and duration of the corresponding neuronal OFF periods. Further investigation suggested that this is due to a disruption in the synchronisation of cortical neurons. Our data suggest that the state of global sleep and local cortical synchrony can be dissociated, and that the brain state induced by benzodiazepines is qualitatively different from spontaneous physiological sleep.
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