ArticleESC heart failure2021
Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry.
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Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Prognostic factors of Takotsubo cardiomyopathy: a systematic review.ESC heart failure · 2021Pooled it
- Cardiac Assessment and Takotsubo-stunning among COPD-exacerbations in-Hospital (CATCH study): when the lungs break your heart-protocol for a prospective observational cohort study.BMJ open respiratory research · 2026Article
- Recovery beyond ejection fraction after takotsubo syndrome: a multidimensional framework for risk-enriched follow-up.Frontiers in cardiovascular medicine · 2026Review
- Long-Term Prognosis, Risk Assessment, and Management of Patients Diagnosed with Takotsubo Syndrome: A Narrative Review.Journal of personalized medicine · 2025Review
- When Is the Broken Heart Most Dangerous? Assessing Risk Factors to Predict Inpatient Death in Takotsubo Cardiomyopathy: Analysis of the National Inpatient Sample for 2021.Journal of the American Heart Association · 2025Article
- Myasthenic Crisis and Concomitant Takotsubo Syndrome Complicated by Shock.Internal medicine (Tokyo, Japan) · 2024Article
- Article
- Review
- Takotsubo cardiomyopathy after solid organ transplantation: a scoping review.Annals of medicine and surgery (2012) · 2024Article
- Cardiovascular and Noncardiovascular Prescribing and Mortality After Takotsubo Comparison With Myocardial Infarction and General Population.JACC. Advances · 2024Article
- Onset of takotsubo syndrome induced by osimertinib in a patient with lung adenocarcinoma.Respiratory medicine case reports · 2024Article
- Triggers, characteristics, and hospital outcome of patients with Takotsubo syndrome: 10 years experience in a large university hospital centre.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Takotsubo syndrome and respiratory diseases: a systematic review.European heart journal open · 2022Review
- Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry.ESC heart failure · 2021Article
- Takotsubo Syndrome: Optimizing Care with a Multidisciplinary Approach.Journal of multidisciplinary healthcare · 2021Review
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Authors and funding
113 authors at 20 institutions in 18 countries.
Ken KatoDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Victoria L CammannDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
L Christian NappDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Konrad A SzawanDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Jozef MicekDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Sara DreidingDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Rena A LevinsonDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Vanya PetkovaDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Michael WürdingerDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Alexandru PatrascuDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Rafael SumalinogDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Sebastiano GiliCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Christian F ClarenbachPulmonary Division, University Hospital of Zurich, Zurich, Switzerland.
Malcolm KohlerPulmonary Division, University Hospital of Zurich, Zurich, Switzerland.
Manfred WischnewskyFB Mathematics and Computer Science, University of Bremen, Bremen, Germany.
Rodolfo CitroHeart Department, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, Italy.
Carmine VecchioneHeart Department, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, Italy.
Eduardo BossoneDivision of Cardiology, Antonio Cardarelli Hospital, Naples, Italy.
Michael NeuhausDepartment of Cardiology, Kantonsspital Frauenfeld, Frauenfeld, Switzerland.
Jennifer FrankeDepartment of Cardiology, Heidelberg University Hospital, Heidelberg, Germany.
Benjamin MederDepartment of Cardiology, Heidelberg University Hospital, Heidelberg, Germany.
Milosz JaguszewskiFirst Department of Cardiology, Medical University of Gdansk, Gdansk, Poland.
Michel NoutsiasDepartment of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Maike KnorrCenter for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Susanne HeinerCenter for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Fabrizio D'AscenzoDivision of Cardiology, Department of Medical Sciences, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy.
Wolfgang DichtlUniversity Hospital for Internal Medicine III (Cardiology and Angiology), Medical University Innsbruck, Innsbruck, Austria.
Christof BurgdorfHeart and Vascular Centre Bad Bevensen, Bad Bevensen, Germany.
Behrouz KheradDepartment of Cardiology, Charité, Campus Rudolf Virchow, Berlin, Germany.
Carsten TschöpeDepartment of Cardiology, Charité, Campus Rudolf Virchow, Berlin, Germany.
Annahita SarconSection of Cardiac Electrophysiology, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Jerold ShinbaneDivision of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lawrence RajanTJ Health Partners Heart and Vascular, Glasgow, KY, USA.
Guido MichelsDepartment of Internal Medicine III, Heart Center University of Cologne, Cologne, Germany.
Roman PfisterDepartment of Internal Medicine III, Heart Center University of Cologne, Cologne, Germany.
Alessandro CuneoKrankenhaus 'Maria Hilf' Medizinische Klinik, Stadtlohn, Germany.
Claudius JacobshagenClinic for Cardiology and Pneumology, Georg August University of Goettingen, Goettingen, Germany.
Mahir KarakasDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Wolfgang KoenigDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Alexander PottDepartment of Internal Medicine II - Cardiology, University of Ulm, Medical Center, Ulm, Germany.
Philippe MeyerService de Cardiologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Marco RoffiService de Cardiologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Adrian BanningDepartment of Cardiology, John Radcliffe Hospital, Oxford University Hospitals, Oxford, UK.
Mathias WolfrumDepartment of Cardiology, Kantonsspital Lucerne, Lucerne, Switzerland.
Florim CuculiDepartment of Cardiology, Kantonsspital Lucerne, Lucerne, Switzerland.
Richard KobzaDepartment of Cardiology, Kantonsspital Lucerne, Lucerne, Switzerland.
Thomas A FischerDepartment of Cardiology, Kantonsspital Winterthur, Winterthur, Switzerland.
Tuija VasankariHeart Center, Turku University Hospital, University of Turku, Turku, Finland.
K E Juhani AiraksinenHeart Center, Turku University Hospital, University of Turku, Turku, Finland.
Monika BudnikDepartment of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Rafal DworakowskiDepartment of Cardiology, King's College Hospital, London, UK.
Philip MacCarthyDepartment of Cardiology, King's College Hospital, London, UK.
Christoph KaiserDepartment of Cardiology, University Hospital of Basel, Basel, Switzerland.
Stefan OsswaldDepartment of Cardiology, University Hospital of Basel, Basel, Switzerland.
Leonarda GaliutoFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Christina ChanDepartment of Cardiology, Christchurch Hospital, Christchurch, New Zealand.
Paul BridgmanDepartment of Cardiology, Christchurch Hospital, Christchurch, New Zealand.
Daniel BeugDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Clément DelmasDepartment of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, France.
Olivier LairezDepartment of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, France.
Ekaterina GilyarovaIntensive Coronary Care Unit, Moscow City Hospital # 1 named after N. Pirogov, Moscow, Russia.
Alexandra ShilovaIntensive Coronary Care Unit, Moscow City Hospital # 1 named after N. Pirogov, Moscow, Russia.
Mikhail GilyarovIntensive Coronary Care Unit, Moscow City Hospital # 1 named after N. Pirogov, Moscow, Russia.
Ibrahim El-BattrawyFirst Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
Ibrahim AkinFirst Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
Martin KozelCardiocenter, Third Faculty of Medicine, Charles University in Prague, University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Petr TousekCardiocenter, Third Faculty of Medicine, Charles University in Prague, University Hospital Kralovske Vinohrady, Prague, Czech Republic.
David E WinchesterDivision of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Jan GaluszkaDepartment of Internal Medicine I - Cardiology, University Hospital Olomouc, Olomouc, Czech Republic.
Christian UkenaKlinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg, Germany.
Gregor PoglajenAdvanced Heart Failure and Transplantation Center, University Medical Center Ljubljana, Ljubljana, Slovenia.
Pedro Carrilho-FerreiraCardiology Department, Santa Maria University Hospital (CHLN), Lisbon Academic Medical Centre and Cardiovascular Centre of the University of Lisbon (CCUL), Lisbon School of Medicine, Universidade de Lisboa, Lisbon, Portugal.
Christian HauckDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Carla PaoliniLocal Health Unit n.8, Cardiology Unit, Arzignano, Vicenza, Italy.
Claudio BilatoLocal Health Unit n.8, Cardiology Unit, Arzignano, Vicenza, Italy.
Masanori SanoDepartment of Cardiology, Chiba Emergency Medical Center, Chiba, Japan.
Iwao IshibashiDepartment of Cardiology, Chiba Emergency Medical Center, Chiba, Japan.
Masayuki TakaharaDivision of Cardiology, Kimitsu Central Hospital, Kisarazu, Japan.
Toshiharu HimiDivision of Cardiology, Kimitsu Central Hospital, Kisarazu, Japan.
Yoshio KobayashiDepartment of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Abhiram PrasadDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Charanjit S RihalDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Kan LiuDivision of Cardiology, Heart and Vascular Center, University of Iowa, Iowa City, Iowa, USA.
P Christian SchulzeDepartment of Internal Medicine I, JenaUniversity Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
Matteo BiancoDivision of Cardiology, A.O.U San Luigi Gonzaga, Turin, Italy.
Lucas JörgDepartment of Cardiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Hans RickliDepartment of Cardiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Gonçalo PestanaDepartment of Cardiology, Centro Hospitalar Universitário de São João, E.P.E, Porto, Portugal.
Thanh H NguyenDepartment of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
Michael BöhmKlinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg, Germany.
Lars S MaierDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Fausto J PintoCardiology Department, Santa Maria University Hospital (CHLN), Lisbon Academic Medical Centre and Cardiovascular Centre of the University of Lisbon (CCUL), Lisbon School of Medicine, Universidade de Lisboa, Lisbon, Portugal.
Petr WidimskýCardiocenter, Third Faculty of Medicine, Charles University in Prague, University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Stephan B FelixDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Grzegorz OpolskiDepartment of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Ruediger C Braun-DullaeusInternal Medicine/Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany.
Wolfgang RottbauerDepartment of Internal Medicine II - Cardiology, University of Ulm, Medical Center, Ulm, Germany.
Gerd HasenfußClinic for Cardiology and Pneumology, Georg August University of Goettingen, Goettingen, Germany.
Burkert M PieskeDepartment of Cardiology, Charité, Campus Rudolf Virchow, Berlin, Germany.
Heribert SchunkertDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Martin BorggrefeFirst Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
Holger ThieleDepartment of Internal Medicine/Cardiology, Heart Center Leipzig - University Hospital, Leipzig, Germany.
Johann BauersachsDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Hugo A KatusDepartment of Cardiology, Heidelberg University Hospital, Heidelberg, Germany.
John D HorowitzDepartment of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
Carlo Di MarioStructural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Thomas MünzelCenter for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Filippo CreaFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.
Thomas F LüscherCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland.
Frank RuschitzkaDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Jelena R GhadriDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Christian TemplinDepartment of Cardiology, University Heart Center, University Hospital of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
University Hospital of Zurich · CHHeidelberg University · DECharité - Universitätsmedizin Berlin · DECity Clinical Hospital · RUGerman Centre for Cardiovascular Research · DELuzerner Kantonsspital · CHCharles University · CZChristchurch Hospital · NZHôpital Beau-Séjour · CHHôpital Rangueil · FRInternational Renal Research Institute of Vicenza · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITKantonsspital St. Gallen · CHKing's College Hospital · GBKisarazu Hospital · JPMedical University of Warsaw · PLMedizinische Hochschule Hannover · DEOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · ITTurku University Hospital · FIUniversitätsklinikum des Saarlandes · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAcute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. METHODS AND
resultsPatients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33-3.38; P = 0.002).
conclusionsThe present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome.
Indexed as
Takotsubo CardiomyopathyHumansPrognosisRegistriesShock, CardiogenicSurvival AnalysisAcute respiratory insufficiencyBroken heart syndromeChronic obstructive pulmonary diseaseInterTAK RegistryOutcomeTakotsubo syndrome
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