ArticleCNS neuroscience & therapeutics2021
Aberrant multimodal brain networks in patients with anti-NMDA receptor encephalitis.
Article in CNS neuroscience & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Brain imaging reveals hierarchical topology changes and stage-dependent impairments in autoimmune encephalitis.Journal of neurology · 2026Article
- Microstructural white matter alterations and cognitive impairment in anti-NMDAR encephalitis: evidence from T1w/T2w ratio analysis.Frontiers in immunology · 2026Article
- Functional Connectivity Changes of Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Graph-Theoretic and Topology-Based Study.Brain and behavior · 2025Article
- Long-Term Cognitive, Functional, and Patient-Reported Outcomes in Patients With Anti-NMDAR Encephalitis.Neurology · 2024Article
- Review
- Examining cognition and brain networks using magnetoencephalography in paediatric autoimmune encephalitis and acute disseminated encephalomyelitis: a preliminary study.Brain communications · 2024Article
- Neuropsychological Testing in Autoimmune Encephalitis: A Scoping Review.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- The micro and macro interactions in acute autoimmune encephalitis: a study of resting-state EEG.Frontiers in neurology · 2023Article
- Efficacy of tocilizumab in anti- N -methyl-d-asparate receptor encephalitis with Graves' hyperthyroidism and positive anti-glial fibrillary acidic protein antibodies.CNS neuroscience & therapeutics · 2022Article
- Cerebral Metabolic Network in Patients With Anti-Frontiers in neuroscience · 2022Article
- Diffusion kurtosis imaging and diffusion tensor imaging parameters applied to white matter and gray matter of patients with anti-N-methyl-D-aspartate receptor encephalitis.Frontiers in neuroscience · 2022Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimsTo explore large-scale brain network alterations and examine their clinical and neuropsychological relevance in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.
methodsTwenty-four patients with anti-NMDAR encephalitis and 26 matched healthy controls (HCs) were enrolled in our study. Based on the multimodal MRI dataset, individual morphological, structural, and functional brain networks were constructed and compared between the two groups at multiple levels. The associations with clinical/neuropsychological variables and the discriminant ability of significant alterations were further studied.
resultsMultimodal network analysis revealed that anti-NMDAR encephalitis mainly affected morphological and structural networks, but subtle alterations were observed in functional networks. Intriguingly, decreased network local efficiency was observed for both morphological and structural networks and increased nodal centrality in the lateral orbital gyrus was convergently observed among the three types of networks in the patients. Moreover, the alterations, particularly those from structural networks, accounted largely for cognitive deficits of the patients and could distinguish the diseased individuals from the HCs with excellent performance (area under the curve =0.933).
conclusionsThe current study provides a comprehensive view of characteristic multimodal network dysfunction in anti-NMDAR encephalitis, which is crucial to establish new diagnostic biomarkers and promising therapeutic targets for the disease.
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