Evidence map›Paper›PMID 33713519›Full record

ArticleJournal of neuroendocrinology2021

Evidence that synaptic plasticity of glutamatergic inputs onto KNDy neurones during the ovine follicular phase is dependent on increasing levels of oestradiol.

Danielle T Porter, Robert L Goodman, Stanley M Hileman, Michael N Lehman

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Danielle T PorterNeuroscience Graduate Program, Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-8042-3251
Robert L GoodmanDepartment of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.ORCID 0000-0003-4080-2596
Stanley M HilemanDepartment of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.
Michael N LehmanBrain Health Research Institute and Department of Biological Sciences, Kent State University, Kent, OH, USA.ORCID 0000-0002-9076-5108
West Virginia University · USKent State University · USUniversity of Mississippi Medical Center · US

Funding

OPIOID REGULATION OF GNRH PULSESR01HD039916 · NICHD · UNIVERSITY OF WESTERN ONTARIO · PI GOODMAN, ROBERT L., LEHMAN, MICHAEL N · 2001 to 2017
$4.9M
Role of NKB in the control of GnRH secretion by ovarian steroidsR01HD082135 · NICHD · WEST VIRGINIA UNIVERSITY · PI GOODMAN, ROBERT L., LEHMAN, MICHAEL N · 2016 to 2020
$2.4M
Heterogeneity among KNDy neurons in their functions and responses to ovarian steroids.F31HD095605 · NICHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI PORTER, DANIELLE TIFFANY · 2018 to 2019
$65k
NICHD NIH HHS F31 HD095605NICHD NIH HHS R01 HD039916NICHD NIH HHS R01 HD082135
6 · The paper itself

Abstract

Neurones in the arcuate nucleus co-expressing kisspeptin, neurokinin B (NKB) and dynorphin (KNDy) play a critical role in the control of gonadotrophin-releasing hormone (GnRH) and luteinising hormone (LH) secretion. In sheep, KNDy neurones mediate both steroid-negative- and -positive-feedback during pulsatile and preovulatory surge secretions of GnRH/LH, respectively. In addition, KNDy neurones receive glutamatergic inputs expressing vGlut2, a glutamate transporter that serves as a marker for those terminals, from both KNDy neurones and other populations of glutamatergic neurones. Previous work reported higher numbers of vGlut2-positive axonal inputs onto KNDy neurones during the LH surge than in luteal phase ewes. In the present study, we further examined the effects of the ovarian steroids progesterone (P) and oestradiol (E

Indexed as

AnimalsDynorphinsEstradiolFemaleFollicular PhaseGlutamatesGonadotropin-Releasing HormoneKisspeptinsLuteal PhaseLuteinizing HormoneNeurokinin BNeuronal PlasticityOvariectomySheepSynapsesVesicular Glutamate Transport Protein 2DynorphinsEstradiolGlutamatesGonadotropin-Releasing HormoneKisspeptinsLuteinizing HormoneNeurokinin BVesicular Glutamate Transport Protein 2arcuateGnRHKNDyplasticityvGlut2

Identifiers

PMID33713519
PMCPMC7959185
OpenAlexW3136018634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.