Evidence map›Paper›PMID 33713401›Full record

ArticleAging2021

A COVID-19 risk score combining chest CT radiomics and clinical characteristics to differentiate COVID-19 pneumonia from other viral pneumonias.

Zuhua Chen, Xiadong Li, Jiawei Li, Shirong Zhang, Pengfei Zhou, Xin Yu, Yao Ren, Jiahao Wang, Lidan Zhang, Yunjiang Li and 13 more

Abstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. CT-based radiomics nomogram for distinguishingTranslational pediatrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Zuhua ChenDepartment of Radiology, Hangzhou Xixi Hospital, Hangzhou 310000, Zhejiang, China.
Xiadong LiDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Jiawei LiDepartment of Radiology, The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang, China.
Shirong ZhangDepartment of Radiation Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China.
Pengfei ZhouDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Xin YuDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Yao RenDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Jiahao WangDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Lidan ZhangDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Yunjiang LiDepartment of Radiology, Hangzhou Xixi Hospital, Hangzhou 310000, Zhejiang, China.
Baoliang WuDepartment of Radiology, Hangzhou Xixi Hospital, Hangzhou 310000, Zhejiang, China.
Yanchun HouDepartment of Radiology, Hangzhou Xixi Hospital, Hangzhou 310000, Zhejiang, China.
Ke ZhangDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Rongjun TangDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Yongguang LiuDepartment of Radiology, Hangzhou Xixi Hospital, Hangzhou 310000, Zhejiang, China.
Zhongxian DingDepartment of Radiation Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China.
Bin YangDepartment of Radiation Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China.
Qinghua DengDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Qin LinDepartment of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen 361003, Fujian, China.
Ke NieDepartment of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ 07097, USA.
Zhaobin CaiDepartment of Radiology, Hangzhou Xixi Hospital, Hangzhou 310000, Zhejiang, China.
Shenglin MaDepartment of Radiation Oncology, Hangzhou Cancer Hospital, Zhejiang University Cancer Centre, Hangzhou First People's Hospital Group, Hangzhou 310000, Zhejiang, China.
Yu KuangMedical Physics Program, University of Nevada, Las Vegas, NV 89154, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the continued transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) throughout the world, identification of highly suspected COVID-19 patients remains an urgent priority. In this study, we developed and validated COVID-19 risk scores to identify patients with COVID-19. In this study, for patient-wise analysis, three signatures, including the risk score using radiomic features only, the risk score using clinical factors only, and the risk score combining radiomic features and clinical variables, show an excellent performance in differentiating COVID-19 from other viral-induced pneumonias in the validation set. For lesion-wise analysis, the risk score using three radiomic features only also achieved an excellent AUC value. In contrast, the performance of 130 radiologists based on the chest CT images alone without the clinical characteristics included was moderate as compared to the risk scores developed. The risk scores depicting the correlation of CT radiomics and clinical factors with COVID-19 could be used to accurately identify patients with COVID-19, which would have clinically translatable diagnostic and therapeutic implications from a precision medicine perspective.

Indexed as

COVID-19Diagnosis, DifferentialFemaleHumansMaleMiddle AgedPneumonia, ViralRiskSARS-CoV-2ThoraxTomography, X-Ray Computedchest CTcoronavirus disease 2019COVID-19nomogramradiomicssevere acute respiratory syndrome coronavirus 2

Identifiers

PMID33713401
PMCPMC8064216

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.