ArticleLiver international : official journal of the International Association for the Study of the Liver2021
Prolonged exposure to welding fumes as a novel cause of systemic iron overload.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Occupational health risks and safety awareness among welders in Nepal, a qualitative study.BMJ open · 2025Article
- A welder case with secondary haemochromatosis, which rarely accompanies pneumoconiosis.Occupational medicine (Oxford, England) · 2025Article
- Consensus Statement on the definition and classification of metabolic hyperferritinaemia.Nature reviews. Endocrinology · 2023Review
- Hereditary Hyperferritinemia.International journal of molecular sciences · 2023Review
- Metal Exposure-Related Welder's Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China.International journal of environmental research and public health · 2022Article
- Iron in Porphyrias: Friend or Foe?Diagnostics (Basel, Switzerland) · 2022Review
- A case of welder's pneumoconiosis treated with corticosteroid followed by nintedanib.Respiratory medicine case reports · 2022Article
- Prolonged exposure to welding fumes as a novel cause of systemic iron overload.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Hyperferritinemia-A Clinical Overview.Journal of clinical medicine · 2021Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsInhalation of welding fume may cause pulmonary disease known as welder's lung. At our centre we came across a number of welders with systemic iron overload and prolonged occupational history and we aimed at characterizing this novel clinical form of iron overload.
methodsAfter exclusion of other known causes of iron overload, 20 welders were fully evaluated for working history, hepatic, metabolic and iron status. MRI iron assessment was performed in 19 patients and liver biopsy in 12. We included 40 HFE-HH patients and 24 healthy controls for comparison.
results75% of patients showed lung HRCT alterations; 90% had s-FERR > 1000 ng/mL and 60% had TSAT > 45%. Liver iron overload was mild in 8 and moderate-severe in 12. The median iron removed was 7.8 g. Welders showed significantly lower TSAT and higher SIS and SIS/TIS ratio than HFE-HH patients. Serum hepcidin was significantly higher in welders than in HFE-HH patients and healthy controls. At liver biopsy, 50% showed liver fibrosis that was mild in four, and moderate-severe in two. Liver staging correlated with liver iron overload.
conclusionsWelders with prolonged fume exposure can develop severe liver iron overload. The mechanism of liver iron accumulation is quite different to that of HFE-HH suggesting that reticuloendothelial cells may be the initial site of deposition. We recommend routine measurement of serum iron indices in welders to provide adequate diagnosis and therapy, and the inclusion of prolonged welding fume exposure in the list of acquired causes of hyperferritinemia and iron overload.
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