ArticleCNS drugs2021
Problem Gambling Associated with Aripiprazole: A Nested Case-Control Study in a First-Episode Psychosis Program.
Article in CNS drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05686772 (A Better Understanding of the Association Between Problem Gambling and Psychotic Disorders in Young Adults), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Better Understanding of the Association Between Problem Gambling and Psychotic Disorders in Young Adults: a New Path Towards Recovery
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of schizophrenia spectrum and other psychotic disorders in problem gambling: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- The Effect of Dopaminergic Medication on Impulse Control and Compulsive Behaviour: A Translational Perspective.Basic & clinical pharmacology & toxicology · 2026Review
- Gaming Disorder in First Episode Psychosis: Prevalence and Impact on Symptomatology and Functioning in a Prospective Cohort Study.Schizophrenia bulletin · 2026Article
- Incidence and predictors of problem gambling in first-episode psychosis: A prospective multicentre cohort study.European psychiatry : the journal of the Association of European Psychiatrists · 2026Observational
- Dopaminergic Genetic Variation and Trait Impulsivity: The Role ofLife (Basel, Switzerland) · 2025Article
- Sexual reactivation under aripiprazole in schizophrenia: a note for prescribers.Journal of psychiatry & neuroscience : JPN · 2025Article
- Evolving diagnosis and comorbidities of gaming disorder: Insights from psychiatry departments in five Chinese hospitals from 2018 to 2023.Journal of behavioral addictions · 2025Observational
- Moderating effect of alexithymia between problem gambling and psychotic experiences in university students.BMC psychiatry · 2024Article
- Disordered gambling among people with psychotic disorders: a systematic review.Schizophrenia (Heidelberg, Germany) · 2024Review
- Problem gambling among people with first-episode psychosis: protocol for a prospective multicenter cohort study.BMC psychiatry · 2023Article
- Internet Gaming Disorders and Early Onset Psychosis in Young People: A Case Study and Clinical Observations.International journal of environmental research and public health · 2023Article
- High dose antipsychotic polypharmacy and dopamine partial agonists - time to rethink guidelines?Journal of psychopharmacology (Oxford, England) · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAripiprazole has been linked to cases of problem gambling (PBG), but evidence supporting this association remains preliminary. Additionally, data specific to PBG in individuals with first-episode psychosis (FEP) receiving aripiprazole are limited to a few case reports, even though aripiprazole is widely used among this population that might be especially vulnerable to PBG.
methodsTo examine this association, a nested case-control study was conducted in a cohort of 219 patients followed at a FEP program located in the Quebec City, Quebec, Canada, metropolitan area. Fourteen cases meeting the PBG criteria according to the Problem Gambling Severity Index were identified and matched for gender and index date to 56 control subjects.
resultsIn the univariable conditional logistic regression analysis, the use of aripiprazole was associated with an increased risk of PBG (odds ratio [OR] 15.2; 95% confidence interval [CI] 2.1-670.5). Cases were more likely to have a prior gambling history (either recreational or problematic) than controls at admittance in the program; they were also more frequently in a relationship and employed. After adjustment for age, relationship status, employment and Cluster B personality disorders, the use of aripiprazole remained associated with an increased risk of PBG (OR 8.6 [95% CI 1.5-227.2]).
conclusionsFindings from this study suggest that FEP patients with a gambling history, problematic or not, may be at increased risk of developing PBG when receiving aripiprazole. They also highlight the importance of systematically screening for PBG all individuals with psychotic disorders, as this comorbidity hinders recovery. While the results also add credence to a causal association between aripiprazole and PBG, further prospective studies are needed to address some of the limitations of this present study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.