Evidence map›Paper›PMID 33713188›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Fully digital pathology laboratory routine and remote reporting of oral and maxillofacial diagnosis during the COVID-19 pandemic: a validation study.

Anna Luíza Damaceno Araújo, Gleyson Kleber do Amaral-Silva, Maria Eduarda Pérez-de-Oliveira, Karen Patricia Domínguez Gallagher, Cinthia Veronica Bardalez López de Cáceres, Ana Luiza Oliveira Corrêa Roza, Amanda Almeida Leite, Bruno Augusto Linhares Almeida Mariz, Carla Isabelly Rodrigues-Fernandes, Felipe Paiva Fonseca and 8 more

Abstract readValidation Study
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Oral pathology and oral medicine in Latin American countries: current stage.Medicina oral, patologia oral y cirugia bucal · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Integrating digital pathology into clinical practice.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anna Luíza Damaceno AraújoOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Gleyson Kleber do Amaral-SilvaOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Maria Eduarda Pérez-de-OliveiraOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Karen Patricia Domínguez GallagherOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Cinthia Veronica Bardalez López de CáceresOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Ana Luiza Oliveira Corrêa RozaOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Amanda Almeida LeiteOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Bruno Augusto Linhares Almeida MarizOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Carla Isabelly Rodrigues-FernandesOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Felipe Paiva FonsecaDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Marcio Ajudarte LopesOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Paul M SpeightUnit of Oral & Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Syed Ali KhurramUnit of Oral & Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Jacks Jorge JúniorOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Manoela Domingues MartinsDepartment of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Oslei Paes de AlmeidaOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Alan Roger Santos-SilvaOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil.
Pablo Agustin VargasOral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areião, Piracicaba, SP, 13414-903, Brazil. pavargas@unicamp.br.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2009/53839-2
6 · The paper itself

Abstract

The role of digital pathology in remote reporting has seen an increase during the COVID-19 pandemic. Recently, recommendations had been made regarding the urgent need of reorganizing head and neck cancer diagnostic services to provide a safe work environment for the staff. A total of 162 glass slides from 109 patients over a period of 5 weeks were included in this validation and were assessed by all pathologists in both analyses (digital and conventional) to allow intraobserver comparison. The intraobserver agreement between the digital method (DM) and conventional method (CM) was considered almost perfect (κ ranged from 0.85 to 0.98, with 95% CI, ranging from 0.81 to 1). The most significant and frequent disagreements within trainees encompassed epithelial dysplasia grading and differentiation among severe dysplasia (carcinoma in situ) and oral squamous cell carcinoma. The most frequent pitfall from DM was lag in screen mirroring. The lack of details of inflammatory cells and the need for a higher magnification to assess dysplasia were pointed in one case each. The COVID-19 crisis has accelerated and consolidated the use of online meeting tools, which would be a valuable resource even in the post-pandemic scenario. Adaptation in laboratory workflow, the advent of digital pathology and remote reporting can mitigate the impact of similar future disruptions to the oral and maxillofacial pathology laboratory workflow avoiding delays in diagnosis and report, to facilitate timely management of head and neck cancer patients. Graphical abstract.

Indexed as

COVID-19Digital TechnologyImage Interpretation, Computer-AssistedMicroscopyTelepathologyBiopsyCarcinoma in SituDiagnosis, DifferentialHumansMaxillary NeoplasmsMouth NeoplasmsObserver VariationPredictive Value of TestsReproducibility of ResultsSquamous Cell Carcinoma of Head and NeckWorkflowCOVID-19Digital microscopyDigital pathologyLaboratory workflowOral and maxillofacial pathologyRemote reporting

Identifiers

PMID33713188
PMCPMC7955219

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.