Evidence map›Paper›PMID 33713043›Full record

ReviewImmunological reviews2021

The double-edged sword of Tregs in M tuberculosis, M avium, and M absessus infection.

Deepshikha Verma, Edward D Chan, Diane J Ordway

Abstract readReview
In one paragraph

Review in Immunological reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Caffeine-mediated CD39Frontiers in immunology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Deepshikha VermaMycobacteria Research Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.
Edward D ChanDepartment of Medicine, Rocky Mountain Regional Veterans Affairs Medical Center, Denver, CO, USA.
Diane J OrdwayMycobacteria Research Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0003-0003-326X

Funding

Immune modulation by highly virulent clinical isolates of M.tuberculosisDP2OD006450 · OD · COLORADO STATE UNIVERSITY · PI ORDWAY, DIANE JOYCE · 2009 to 2009
$2.0M
ANIMAL MODEL TESTING OF TB DRUGSN01AI095385 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI ORME, IAN M · 1999 to 2000
$446k
Novel preclinical efficacy models against nontuberculosis mycobacteriaR21AI099534 · NIAID · COLORADO STATE UNIVERSITY · PI ORDWAY, DIANE JOYCE · 2013 to 2014
$409k
Induction of regulatory T cells by highly virulent isolates of M.tuberculosisR21AI081959 · NIAID · COLORADO STATE UNIVERSITY · PI ORDWAY, DIANE JOYCE · 2010 to 2011
$402k
NIAID NIH HHS HHSN272201000009INIAID NIH HHS N01 AI095385NIAID NIH HHS R21 AI081959NIAID NIH HHS R21 AI099534NIH HHS DP2 OD006450
6 · The paper itself

Abstract

Immunity against different Mycobacteria species targeting the lung requires distinctly different pulmonary immune responses for bacterial clearance. Many parameters of acquired and regulatory immune responses differ quantitatively and qualitatively from immunity during infection with Mycobacteria species. Nontuberculosis Mycobacteria species (NTM) Mycobacterium avium- (M avium), Mycobacterium abscessus-(M abscessus), and the Mycobacteria species Mycobacterium tuberculosis-(Mtb). Herein, we discuss the potential implications of acquired and regulatory immune responses in the context of animal and human studies, as well as future directions for efforts to treat Mycobacteria diseases.

Indexed as

Mycobacterium abscessusMycobacterium tuberculosisTuberculosisAnimalsHumansMycobacterium aviumImmunityMycobacterium abscessusMycobacterium aviumMycobacterium tuberculosis

Identifiers

PMID33713043
PMCPMC8154666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.