Evidence map›Paper›PMID 33713030›Full record

ReviewTranslational stroke research2021

Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.

Xuejing Zhang, Jaclyn Connelly, Edwin S Levitan, Dandan Sun, Jane Q Wang

Open access · hybridAbstract readReview
In one paragraph

Review in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Toxic Effects of Glyphosate on the Nervous System: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Wnt/CaOncology letters · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. CaeNeuro · 2024
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xuejing ZhangDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, E1354 BST, Pittsburgh, PA, USA.
Jaclyn ConnellyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, E1354 BST, Pittsburgh, PA, USA.
Edwin S LevitanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, E1354 BST, Pittsburgh, PA, USA.
Dandan SunDepartment of Neurology, Pittsburgh Institute For Neurodegenerative Diseases, University of Pittsburgh, 7016 Biomedical Science Tower-3, 3501 Fifth Ave., Pittsburgh, PA, 15260, USA. sund@upmc.edu.
Jane Q WangDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, E1354 BST, Pittsburgh, PA, USA. qjw1@pitt.edu.ORCID http://orcid.org/0000-0002-9502-4851
University of Pittsburgh · US

Funding

The Role of Na+/H+ exchanger in Cerebral IschemiaR01NS048216 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Dandan Sun · 2005 to 2026
$6.1M
American Heart Association (US) 19TPA34850096National Institutes of Health (US) R01NS48216NINDS NIH HHS R01 NS048216
6 · The paper itself

Abstract

Cerebrovascular disease is the most common life-threatening and debilitating condition that often leads to stroke. The multifunctional calcium/calmodulin-dependent protein kinase II (CaMKII) is a key Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2StrokeCalciumHumansNeuroinflammatory DiseasesNeuronsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CaMKIICerebrovascular diseaseEndothelial barrier dysfunctionNeuroinflammationNeuronal cell deathStrokeVascular dementia

Identifiers

PMID33713030
PMCPMC8213567
OpenAlexW3135848534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.