Observational studyJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2021
Association Between Intraoperative Blood Glucose and Anastomotic Leakage in Colorectal Surgery.
Observational study in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A systematic review on biomarkers implemented to measure surgical stress response in patients undergoing colorectal surgery.International journal of colorectal disease · 2025Pooled it
- Association of preoperative insulin resistance surrogate indices with the risk of anastomotic leakage after colorectal cancer resection: a multicenter retrospective cohort.World journal of surgical oncology · 2026Article
- Anastomotic Leak Following Colorectal Surgery.Clinics in colon and rectal surgery · 2026Review
- Development of a Clinical Prediction Model for Anastomotic Leakage in Colorectal Surgery.JAMA network open · 2025Observational
- Postoperative hyperglycemia among adult non-diabetic surgical patients at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.BMC anesthesiology · 2024Article
- Preliminary investigation of the effect of non-cardiac surgery on intraoperative islet and renal function: a single-center prospective cohort study.Frontiers in medicine · 2024Article
- A New Nomogram-Based Prediction Model for Postoperative Outcome after Sigmoid Resection for Diverticular Disease.Medicina (Kaunas, Lithuania) · 2023Article
- Anastomotic leakage after resection of the rectosigmoid colon in primary ovarian cancer.Journal of ovarian research · 2023Article
- Strategies for intraoperative glucose management: a scoping review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Article
- Incidence and risk factors of intraoperative hyperglycemia in non-diabetic patients: a prospective observational study.BMC anesthesiology · 2022Observational
- Comprehensive testing of colorectal anastomosis: results of prospective observational cohort study.Surgical endoscopy · 2022Observational
- Optimized perioperative management (fast-track, ERAS) to enhance postoperative recovery in elective colorectal surgery.GMS hygiene and infection control · 2022Review
- The Efficacy of Targeted Perioperative Management for Diabetic Patients with Traumatic Calcaneal Fractures.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Risk Factors and Preventive Measures for Anastomotic Leak in Colorectal Cancer.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerioperative hyperglycemia is a known risk factor for postoperative complications after colorectal surgery. The aim of this study was to investigate whether intraoperative blood glucose values are associated with colorectal anastomotic leakage in diabetic and non-diabetic patients undergoing colorectal surgery.
methodsThis is an additional analysis of a previously published prospective, observational cohort study (the LekCheck study). Fourteen hospitals in Europe and Australia collected perioperative data. Consecutive adult patients undergoing colorectal surgery with primary anastomosis between 2016 and 2018 were included. From all patients, preoperative diabetic status was known and intraoperative blood glucose was determined just prior to the creation of the anastomosis. The primary outcome was the occurrence of anastomotic leakage within 30 days postoperatively.
resultsOf 1474 patients (mean age 68 years), 224 patients (15%) had diabetes mellitus, 737 patients (50%) had intraoperative hyperglycemia (≥126 mg/dL, ≥7.0 mmol/L), and 129 patients (8.8%) developed anastomotic leakage. Patients with intraoperative hyperglycemia had higher anastomotic leakage rates compared to patients with a normal blood glucose level (12% versus 5%, P<0.001). Anastomotic leakage rate did not significantly differ between diabetic and non-diabetic patients (12% versus 8%, P=0.058). Logistic regression analyses showed that higher blood glucose levels were associated with an increasing leakage risk in non-diabetic patients only.
conclusionIncidence and severity of intraoperative hyperglycemia are associated with anastomotic leakage in non-diabetic patients. Whether hyperglycemia is an epiphenomenon, a marker for other risk factors or a potential modifiable risk factor per se for anastomotic leakage requires future research.
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