Evidence map›Paper›PMID 33712923›Full record

ReviewSeminars in immunopathology2021

Insights into the pathogenesis of psoriatic arthritis from genetic studies.

Sara Rahmati, Quan Li, Proton Rahman, Vinod Chandran

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Predicting Psoriatic Arthritis in Psoriasis Patients - A Swiss Registry Study.Journal of psoriasis and psoriatic arthritis · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Frontiers in medicine · 2022
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sara RahmatiSchroeder Arthritis Institute, Krembil Research Institute, University Heath Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-2009-4660
Quan LiDepartment of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.ORCID https://orcid.org/0000-0002-0565-9045
Proton RahmanDepartment of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.ORCID https://orcid.org/0000-0002-4521-2029
Vinod ChandranSchroeder Arthritis Institute, Krembil Research Institute, University Heath Network, Toronto, Ontario, Canada. vinod.chandran@uhnresearch.ca.ORCID http://orcid.org/0000-0002-8297-0275
Memorial University of Newfoundland · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriatic arthritis (PsA) is a relatively common inflammatory arthritis, a spondyloarthritis (SpA), that occurs most often in patients with psoriasis, a common immune-mediated inflammatory skin disease. Both psoriasis and PsA are highly heritable. Genetic and recent genomic studies have identified variants associated with psoriasis and PsA, but variants differentiating psoriasis from PsA are few. In this review, we describe recent developments in understanding the genetic burden of PsA, linkage, association and epigenetic studies. Using pathway analysis, we provide further insights into the similarities and differences between PsA and psoriasis, as well as between PsA and other immune-mediated inflammatory diseases, particularly ankylosing spondylitis, another SpA. Environmental factors that may trigger PsA in patients with psoriasis are also reviewed. To further understand the pathogenetic differences between PsA and psoriasis as well as other SpA, larger cohort studies of well-phenotyped subjects with integrated analysis of genomic, epigenomic, transcriptomic, proteomic and metabolomic data using interomic system biology approaches are required.

Indexed as

Arthritis, PsoriaticPsoriasisHumansPhenotypeProteomicsEnvironmental factorsGenomicsHeritabilityPathway analysisPsoriasisSpondyloarthritis

Identifiers

PMID33712923
OpenAlexW3134649950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.