Evidence map›Paper›PMID 33712841›Full record

ArticleInternational journal of epidemiology2021

Selection into shift work is influenced by educational attainment and body mass index: a Mendelian randomization study in the UK Biobank.

Iyas Daghlas, Rebecca C Richmond, Jacqueline M Lane, Hassan S Dashti, Hanna M Ollila, Eva S Schernhammer, George Davey Smith, Martin K Rutter, Richa Saxena, Céline Vetter

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Iyas DaghlasBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8735-284X
Rebecca C RichmondMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0003-0574-5071
Jacqueline M LaneBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6101-2855
Hassan S DashtiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1650-679X
Hanna M OllilaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-5302-6429
Eva S SchernhammerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4337-9415
George Davey SmithMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-1407-8314
Martin K RutterDivision of Endocrinology, Diabetes and Gastroenterology, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, UK.ORCID 0000-0001-6380-539X
Richa SaxenaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2233-1065
Céline VetterBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3752-1067
Broad Institute · USUniversity of Bristol · GBBrigham and Women's Hospital · USManchester Academic Health Science Centre · GB

Funding

Genetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0M
Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8M
Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2M
Genetic and molecular basis of circadian rhythm disordersK01HL136884 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2018 to 2022
$848k
Novel Circadian Exposure Metrics for Shift WorkersR21OH011052 · OH · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHERNHAMMER, EVA S · 2016 to 2017
$457k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00011/1MRC Integrative Epidemiology Unit at the University of Bristol funded by the Medical Research Council MC_UU_00011/1NHLBI NIH HHS K01 HL136884NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK107859NIOSH CDC HHS R21 OH011052
6 · The paper itself

Abstract

backgroundShift work is associated with increased cardiometabolic disease risk. This observation may be partly explained by cardiometabolic risk factors having a role in the selection of individuals into or out of shift work. We performed Mendelian randomization (MR) analyses in the UK Biobank (UKB) to test this hypothesis.

methodsWe used genetic risk scores (GRS) to proxy nine cardiometabolic risk factors and diseases (including educational attainment, body mass index (BMI), smoking, and alcohol consumption), and tested associations of each GRS with self-reported frequency of current shift work among employed UKB participants of European ancestry (n = 190 573). We used summary-level MR sensitivity analyses to assess robustness of the identified effects, and we tested whether effects were mediated through sleep timing preference.

resultsGenetically instrumented liability to lower educational attainment (odds ratio (OR) per 3.6 fewer years in educational attainment = 2.40, 95% confidence interval (CI) = 2.22-2.59, P = 4.84 × 10-20) and higher body mass index (OR per 4.7 kg/m2 higher BMI = 1.30, 95% CI = 1.14-1.47, P = 5.85 × 10-5) increased odds of reporting participation in frequent shift work. Results were unchanged in sensitivity analyses allowing for different assumptions regarding horizontal pleiotropy. No selection effects were evident for the remaining exposures, nor for any exposures on selection out of shift work. Sleep timing preference did not mediate the effects of BMI and educational attainment on selection into shift work.

conclusionsLiability to lower educational attainment and higher BMI may influence selection into shift work. This phenomenon may bias epidemiological studies of shift work that are performed in the UKB.

Indexed as

Mendelian Randomization AnalysisShift Work ScheduleBiological Specimen BanksBody Mass IndexGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRisk FactorsUnited KingdomBody mass indexcardiometabolic diseaseconfoundingeducational attainmentMendelian randomizationobesityshift workUK Biobank

Identifiers

PMID33712841
PMCPMC8562336
OpenAlexW3134144599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.