ArticleThe ISME journal2021
Genetic identity and genotype × genotype interactions between symbionts outweigh species level effects in an insect microbiome.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Ecological Mercenaries: Why Aphids Remain Premier Models for the Study of Ecological Symbiosis.Insects · 2025Review
- Heritable symbiont producing nonribosomal peptide confers extreme heat sensitivity and antifungal protection on its host.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Insect-microbe interactions and their influence on organisms and ecosystems.Ecology and evolution · 2024Review
- Intracellular defensive symbiont is culturable and capable of transovarial, vertical transmission.mBio · 2024Article
- Floral presence and flower identity alter cereal aphid endosymbiont communities on adjacent crops.The Journal of applied ecology · 2023Article
- Article
- Disentangling arbuscular mycorrhizal fungi and bacteria at the soil-root interface.Mycorrhiza · 2023Review
- Anopheles albimanus is a Potential Alphavirus Vector in the Americas.The American journal of tropical medicine and hygiene · 2023Article
- Host's genetic background determines the outcome of reciprocal faecal transplantation on life-history traits and microbiome composition.Animal microbiome · 2022Article
- Symbiont-conferred immunity interacts with effects of parasitoid genotype and intraguild predation to affect aphid immunity in a clone-specific fashion.BMC ecology and evolution · 2022Article
- Frequent Drivers, Occasional Passengers: Signals of Symbiont-Driven Seasonal Adaptation and Hitchhiking in the Pea Aphid,Insects · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Microbial symbionts often alter the phenotype of their host. Benefits and costs to hosts depend on many factors, including host genotype, symbiont species and genotype, and environmental conditions. Here, we present a study demonstrating genotype-by-genotype (G×G) interactions between multiple species of endosymbionts harboured by an insect, and the first to quantify the relative importance of G×G interactions compared with species interactions in such systems. In the most extensive study to date, we microinjected all possible combinations of five Hamiltonella defensa and five Fukatsuia symbiotica (X-type; PAXS) isolates into the pea aphid, Acyrthosiphon pisum. We applied several ecological challenges: a parasitoid wasp, a fungal pathogen, heat shock, and performance on different host plants. Surprisingly, genetic identity and genotype × genotype interactions explained far more of the phenotypic variation (on average 22% and 31% respectively) than species identity or species interactions (on average 12% and 0.4%, respectively). We determined the costs and benefits associated with co-infection, and how these compared to corresponding single infections. All phenotypes were highly reliant on individual isolates or interactions between isolates of the co-infecting partners. Our findings highlight the importance of exploring the eco-evolutionary consequences of these highly specific interactions in communities of co-inherited species.
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