ArticleScientific reports2021
Genome-wide transcriptome profiling uncovers differential miRNAs and lncRNAs in ovaries of Hu sheep at different developmental stages.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 53 citations in OpenAlex.
- Whole-Transcriptome Landscape Deciphers a ceRNA-Mediated "De-Repression-Activation" Circuit Governing Continuous Estrus in Ovine.Animals : an open access journal from MDPI · 2026Article
- Genome-Wide Resequencing Reveals Genetic Diversity and Selection Signatures in Two Indigenous Goat Populations From Xizang.Animal genetics · 2026Article
- Detection for New Biomarkers of Tuberculosis Infection Activity Using Machine Learning Methods.Diseases (Basel, Switzerland) · 2026Review
- Genomic insights into the recent evolution and biodiversity of Italian sheep breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Differential Expression of lncRNAs in Ovarian Tissue of Meigu Goats During the Sexually Immature and Mature Periods.Current issues in molecular biology · 2025Article
- Differential expression analysis of lncRNA and mRNA in ovarian tissues of Pishan Red Sheep and Hu Sheep with distinct genotypes during estrus.Frontiers in veterinary science · 2025Article
- Article
- Genetic Diversity, Selection Signatures, and Genome-Wide Association Study Identify Candidate Genes Related to Litter Size in Hu Sheep.International journal of molecular sciences · 2024Article
- Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development.Reproductive biology and endocrinology : RB&E · 2024Article
- Integrative Meta-Analysis: Unveiling Genetic Factors in Meat Sheep Growth and Muscular Development through QTL and Transcriptome Studies.Animals : an open access journal from MDPI · 2024Article
- Astaxanthin Improved the Quality of Hu Ram Semen by Increasing the Antioxidant Capacity and Mitochondrial Potential and Mitigating Free Radicals-Induced Oxidative Damage.Animals : an open access journal from MDPI · 2024Article
- Identification and functional analysis of ovarian lncRNAs during different egg laying periods in Taihe Black-Bone Chickens.Frontiers in physiology · 2024Article
- Comparative analysis of alternative splicing events in skeletal muscle of different sheep.Heliyon · 2023Article
- Comparison of alternative splicing (AS) events in adipose tissue of polled dorset versus small tail han sheep.Heliyon · 2023Article
- Transcriptome Analysis Reveals the Profile of Long Non-Coding RNAs during Myogenic Differentiation in Goats.International journal of molecular sciences · 2023Article
- Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep.BMC genomics · 2023Article
- Identification of differentially expressed genes and signaling pathways in Gaoyou duck ovary at different physiological stages.Frontiers in veterinary science · 2023Article
- CircRNAs in Xiang pig ovaries among diestrus and estrus stages.Porcine health management · 2022Article
- Chlorogenic Acid Improves Quality of Chilled Ram Sperm by Mitigating Oxidative Stress.Animals : an open access journal from MDPI · 2022Article
- Insight Into Pituitary lncRNA and mRNA at Two Estrous Stages in Small Tail Han Sheep With DifferentFrontiers in endocrinology · 2021Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
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Abstract
Ovary development is an important determinant of the procreative capacity of female animals. Here, we performed genome-wide sequencing of long non-coding RNAs (lncRNAs) and mRNAs on ovaries of 1, 3 and 8 months old Hu sheep to assess their expression profiles and roles in ovarian development. We identified 37,309 lncRNAs, 45,404 messenger RNAs (mRNAs) and 330 novel micro RNAs (miRNAs) from the transcriptomic analysis. Six thousand, seven hundred and sixteen (6716) mRNAs and 1972 lncRNAs were significantly and differentially expressed in ovaries of 1 month and 3 months old Hu sheep (H1 vs H3). These mRNAs and target genes of lncRNAs were primarily enriched in the TGF-β and PI3K-Akt signalling pathways which are closely associated with ovarian follicular development and steroid hormone biosynthesis regulation. We identified MSTRG.162061.1, MSTRG.222844.7, MSTRG.335777.1, MSTRG.334059.16, MSTRG.188947.6 and MSTRG.24344.3 as vital genes in ovary development by regulating CTNNB1, CCNA2, CDK2, CDC20, CDK1 and EGFR expressions. A total of 2903 mRNAs and 636 lncRNAs were differentially expressed in 3 and 8 months old ovaries of Hu sheep (H3 vs H8); and were predominantly enriched in PI3K-Akt, progesterone-mediated oocyte maturation, estrogen metabolism, ovulation from the ovarian follicle and oogenesis pathways. These lncRNAs were also found to regulate FGF7, PRLR, PTK2, AMH and INHBA expressions during follicular development. Our result indicates the identified genes participate in the development of the final stages of follicles and ovary development in Hu sheep.
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