Evidence map›Paper›PMID 33712662›Full record

ArticleScientific reports2021

The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer.

Constantinos Zamboglou, Maria Kramer, Selina Kiefer, Peter Bronsert, Lara Ceci, August Sigle, Wolfgang Schultze-Seemann, Cordula A Jilg, Tanja Sprave, Thomas F Fassbender and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Efficacy of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Pooled it
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  3. Article
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  7. Deep learning based automated delineation of the intraprostatic gross tumour volume in PSMA-PET for patients with primary prostate cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023
    Article
  8. Article
  9. [Bioengineering (Basel, Switzerland) · 2023
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  14. Intraindividual Comparison Between [Frontiers in oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Constantinos Zamboglou *Department of Radiation Oncology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Maria Kramer *Department of Radiation Oncology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Selina KieferInstitute for Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Peter BronsertInstitute for Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Lara CeciDepartment of Radiation Oncology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
August SigleDepartment of Urology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Wolfgang Schultze-SeemannDepartment of Urology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Cordula A JilgDepartment of Urology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Tanja SpraveDepartment of Radiation Oncology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Thomas F FassbenderDepartment of Nuclear Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Nils H NicolayDepartment of Radiation Oncology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Juri RufDepartment of Nuclear Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Matthias BenndorfDepartment of Radiology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Anca L GrosuDepartment of Radiation Oncology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Simon K B SpohnDepartment of Radiation Oncology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany. Simon.Spohn@uniklinik-freiburg.de.
University Medical Center Freiburg · DEGerman Cancer Research Center · DEUniversity of Freiburg · DEDeutschen Konsortium für Translationale Krebsforschung · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comparison studies using histopathology as standard of reference enable a validation of the diagnostic performance of imaging methods. This study analysed (1) the impact of different image-histopathology co-registration pathways, (2) the impact of the applied data analysis method and (3) intraindividually compared multiparametric magnet resonance tomography (mpMRI) and prostate specific membrane antigen positron emission tomography (PSMA-PET) by using the different approaches. Ten patients with primary PCa who underwent mpMRI and [

Indexed as

Image Processing, Computer-AssistedMultimodal ImagingAntigens, SurfaceGlutamate Carboxypeptidase IIHumansMagnetic Resonance ImagingMalePositron-Emission TomographyProstatic NeoplasmsSensitivity and SpecificityAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase II

Identifiers

PMID33712662
PMCPMC7954803
OpenAlexW3135659250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.