SynthesisScientific reports2021
A systematic review of movement and muscular activity biomarkers to discriminate non-specific chronic low back pain patients from an asymptomatic population.
Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07176845 (Exploring Multidimensional Trajectories in People With Low Back Pain), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploring Multidimensional Trajectories in People With Low Back Pain
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Using game performance measure to assess upper limb motor function in children with neuromotor disorders: a systematic review.Journal of neuroengineering and rehabilitation · 2025Pooled it
- A systematic review of instrumented assessments for upper limb function in cerebral palsy: current limitations and future directions.Journal of neuroengineering and rehabilitation · 2024Pooled it
- Core Synergies Measured with Ultrasound in Subjects with Chronic Non-Specific Low Back Pain and Healthy Subjects: A Systematic Review.Sensors (Basel, Switzerland) · 2022Pooled it
- Associations between trunk mobility, pain, and quality of life in individuals with chronic low back pain treated with different therapeutic protocols: Potential clinical parameters.Journal of back and musculoskeletal rehabilitation · 2026Trial
- Baseline characteristics of participants in the Biomarkers for Evaluating Spine Treatments clinical trial: a sequential multiple assignment randomized trial for chronic low back pain†.Pain medicine (Malden, Mass.) · 2025Trial
- A new logistic regression model for the detection of chronic low back pain, based on a case-control study in the Spanish population.Asian spine journal · 2026Article
- Article
- Bioengineering Support in the Assessment and Rehabilitation of Low Back Pain.Bioengineering (Basel, Switzerland) · 2025Review
- Article
- Regional flexion relaxation phenomenon in lumbar extensor muscles under delayed-onset muscle soreness: high-density surface electromyography insights.European journal of applied physiology · 2025Article
- Article
- A review and empirical findings of fasciae and muscle interactions in low back pain.Frontiers in physiology · 2025Article
- The investigation of ultrasound to assess lateral abdominal wall activation with different types of core exercises.BMC sports science, medicine & rehabilitation · 2024Article
- Ultrasound Evaluation of Onset Core Muscle Activity in Subjects with Non-Specific Lower Back Pain and Without Lower Back Pain: An Observational Case-Control Study.Diagnostics (Basel, Switzerland) · 2024Article
- Understanding the flexion-relaxation phenomenon in non-specific chronic low back pain patients throught immersive virtual reality feedback approach.Scientific reports · 2024Article
- Lumbar Paravertebral Muscle Pain Management Using Kinesitherapy and Electrotherapeutic Modalities.Healthcare (Basel, Switzerland) · 2024Article
- Marked differences between continuous long-term and clinical snapshot examinations: is the current standard of back pain diagnostics outdated?Frontiers in bioengineering and biotechnology · 2024Article
- The Efficacy and Feasibility of an Interoceptive Exposure Technique for Preventing the Transition From Subacute to Chronic Back Pain by Altering the Emotional Response to Pain: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2023Article
- Biomechanical Phenotyping of Chronic Low Back Pain: Protocol for BACPAC.Pain medicine (Malden, Mass.) · 2023Article
- Mechanical Biomarkers in Bone Using Image-Based Finite Element Analysis.Current osteoporosis reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The identification of relevant and valid biomarkers to distinguish patients with non-specific chronic low back pain (NSCLBP) from an asymptomatic population in terms of musculoskeletal factors could contribute to patient follow-up and to evaluate therapeutic strategies. Several parameters related to movement and/or muscular activity impairments have been proposed in the literature in that respect. In this article, we propose a systematic and comprehensive review of these parameters (i.e. potential biomarkers) and related measurement properties. This systematic review (PROSPERO registration number: CRD42020144877) was conducted in Medline, Embase, and Web of Knowledge databases until July 2019. In the included studies, all movements or muscular activity parameters having demonstrated at least a moderate level of construct validity were defined as biomarkers, and their measurement properties were assessed. In total, 92 studies were included. This allowed to identify 121 movement and 150 muscular activity biomarkers. An extensive measurement properties assessment was found in 31 movement and 14 muscular activity biomarkers. On the whole, these biomarkers support the primary biomechanical concepts proposed for low back pain. However, a consensus concerning a robust and standardised biomechanical approach to assess low back pain is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.