ArticleScientific reports2021
A focused very high energy electron beam for fractionated stereotactic radiotherapy.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- A beam model and Boltzmann solver for radiotherapy treatment planning of superficial brain metastases using a scanned electron beam at ultra-high (FLASH) dose rate.Physics in medicine and biology · 2026Article
- Start-to-end modelling of laser-plasma acceleration, beam transport and dose deposition of very high-energy electrons for radiotherapy.Scientific reports · 2026Article
- Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype.Nature communications · 2025Article
- Leveraging Electron Beam (eBeam) Technology for Advancing the Development of Inactivated Vaccines.Vaccines · 2025Review
- Review
- Combined plasma lens and rephasing stage for a laser wakefield accelerator.Scientific reports · 2024Article
- Treatment planning for very high energy electrons: Studies that indicate the potential of the modality.Physics and imaging in radiation oncology · 2024Review
- Extending deterministic transport capabilities for very-high and ultra-high energy electron beams.Scientific reports · 2024Article
- Transformative Technology for FLASH Radiation Therapy.Applied sciences (Basel, Switzerland) · 2023Article
- Determination of the ion collection efficiency of the Razor Nano Chamber for ultra-high dose-rate electron beams.Medical physics · 2022Article
- Development of Ultra-High Dose-Rate (FLASH) Particle Therapy.IEEE transactions on radiation and plasma medical sciences · 2022Article
- Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy.Cancers · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
An electron beam of very high energy (50-250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (several cm), very large accelerating structures are needed when using conventional radio-frequency technology, which may not be possible due to economical or spatial constraints. In this paper, we show transport and focusing of laser wakefield accelerated electron beams with a maximum energy of 160 MeV using electromagnetic quadrupole magnets in a point-to-point imaging configuration, yielding a spatial uncertainty of less than 0.1 mm, a total charge variation below [Formula: see text] and a focal spot of [Formula: see text]. The electron beam was focused to control the depth dose distribution and to improve the dose conformality inside a phantom of cast acrylic slabs and radiochromic film. The phantom was irradiated from 36 different angles to obtain a dose distribution mimicking a stereotactic radiotherapy treatment, with a peak fractional dose of 2.72 Gy and a total maximum dose of 65 Gy. This was achieved with realistic constraints, including 23 cm of propagation through air before any dose deposition in the phantom.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.