Evidence map›Paper›PMID 33712530›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Exploiting the MUC5AC Antigen for Noninvasive Identification of Pancreatic Cancer.

Kelly E Henry, Travis M Shaffer, Kyeara N Mack, Janine Ring, Anuja Ogirala, Susanne Klein-Scory, Christina Eilert-Micus, Wolff Schmiegel, Thilo Bracht, Barbara Sitek and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Interrogating the Theranostic Capacity of a MUC16-Targeted Antibody for Ovarian Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Kelly E HenryDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; grimmj@mskcc.org.
Travis M ShafferDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; grimmj@mskcc.org.
Kyeara N MackDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Janine RingDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Anuja OgiralaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Susanne Klein-ScoryDepartment of Medicine, Ruhr University Bochum, Bochum, Germany.
Christina Eilert-MicusDepartment of Medicine, Ruhr University Bochum, Bochum, Germany.
Wolff SchmiegelDepartment of Medicine, Ruhr University Bochum, Bochum, Germany.
Thilo BrachtMedical Proteome Center, Ruhr University Bochum, Bochum, Germany.
Barbara SitekMedical Proteome Center, Ruhr University Bochum, Bochum, Germany.
Marguerite ClyneSchool of Medicine, Health Sciences Centre, University College Dublin, Dublin, Ireland.
Colm J ReidSchool of Medicine, Health Sciences Centre, University College Dublin, Dublin, Ireland.
Bence SiposDepartment of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Holger KalthoffInstitute for Experimental Cancer Research, Christian-Albrechts University, Kiel, Germany.
Jan GrimmDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; grimmj@mskcc.org.
Ruhr University Bochum · DEMemorial Sloan Kettering Cancer Center · USCornell University · USUniversity College Dublin · IEKiel University · DEStanford University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130
6 · The paper itself

Abstract

Pancreatic cancer (PC) remains the fourth leading cause of cancer death; therefore, there is a clinically unmet need for novel therapeutics and diagnostic markers to treat this devastating disease. Physicians often rely on biopsy or CT for diagnosis, but more specific protein biomarkers are highly desired to assess the stage and severity of PC in a noninvasive manner. Serum biomarkers such as carbohydrate antigen 19-9 are of particular interest as they are commonly elevated in PC but have exhibited suboptimal performance in the clinic. MUC5AC has emerged as a useful serum biomarker that is specific for PC versus inflammation. We developed RA96, an anti-MUC5AC antibody, to gauge its utility in PC diagnosis through immunohistochemical analysis and whole-body PET in PC.

Indexed as

Mucin 5ACPancreatic NeoplasmsPositron-Emission TomographyAnimalsBiomarkers, TumorCell Line, TumorFemaleHumansImmunohistochemistryMiceRadioisotopesZirconiumBiomarkers, TumorMUC5AC protein, humanMucin 5ACRadioisotopesZirconiumZirconium-8989Zrimmuno-PETMUC5ACpancreatic cancerRA96

Identifiers

PMID33712530
PMCPMC8724889
OpenAlexW3134357513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.