Evidence map›Paper›PMID 33712516›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2021

Bernard P H Cho, Stefania Nannoni, Eric L Harshfield, Daniel Tozer, Stefan Gräf, Steven Bell, Hugh S Markus

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07497867 (Long-term Prognosis of Korean Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07497867 recruitingnot on this mapstarted 2023, after this paper: background citation

Long-term Prognosis of Korean Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy(CADASIL) Patients: A Multicenter Prospective Study

Typeobservational_patient_registrySponsorJeju National University HospitalRan2023 to 2040Enrolled500ConditionsCADASIL, Cerebral Autosomal Dominant Arteriopatie With Subcortical Infarcts and Leukoencephalopathy
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. The Spectrum ofGenes · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Is migraine a common manifestation of CADASIL-Cons.The journal of headache and pain · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bernard P H ChoDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK.ORCID 0000-0002-5034-3234
Stefania NannoniDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK.
Eric L HarshfieldDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK.ORCID 0000-0001-8767-0928
Daniel TozerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK.
Stefan GräfDepartment of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
Steven BellDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK.
Hugh S MarkusDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK hsm32@medschl.cam.ac.uk.ORCID 0000-0002-9794-5996
University of Cambridge · GB

Funding

British Heart Foundation RG/16/4/32218British Heart Foundation RG/4/32218Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/N026896/1
6 · The paper itself

Abstract

backgroundCysteine-altering

methodsCysteine-altering

resultsOf 200 632 participants with exome sequencing data available, 443 (~1 in 450) carried 67 different cysteine-altering

conclusionsCysteine-changing

Indexed as

Genetic Predisposition to DiseaseAdultAgedBrainCADASILDementia, VascularFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReceptor, Notch3StrokeReceptor, Notch3

Identifiers

PMID33712516
PMCPMC8223663
OpenAlexW3133648895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.