ArticleScience immunology2021
Deep-sea microbes as tools to refine the rules of innate immune pattern recognition.
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In one paragraph
Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
What it found
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Metabolic Flux Analysis Reveals Entner-Doudoroff Pathway Dominance in Heterotrophic Deep-Sea Bacterial Isolates.Environmental microbiology reports · 2026Article
- Rapid mid-Cretaceous diversification of squid and cuttlefish preceded radiation into coastal niches.Nature ecology & evolution · 2026Article
- DMEM and EMEM as alternate growth media for pathogenic Leptospira.PLoS neglected tropical diseases · 2026Article
- Structural and Immunological Insights into the Lipooligosaccharide of the Marine BacteriumMarine drugs · 2025Article
- Biological and clinical implications of a model of surveillance immunity.The Journal of clinical investigation · 2025Review
- Disruption of MRSA Biofilm and Virulence by Deep-Sea Probiotics: Impacts on Energy metabolism and Host Antimicrobial Peptides.Probiotics and antimicrobial proteins · 2025Article
- How little we've seen: A visual coverage estimate of the deep seafloor.Science advances · 2025Article
- DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies usingbioRxiv : the preprint server for biology · 2025Article
- Oceanic Breakthroughs: Marine-Derived Innovations in Vaccination, Therapy, and Immune Health.Vaccines · 2024Review
- The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Advances in Extremophile Research: Biotechnological Applications through Isolation and Identification Techniques.Life (Basel, Switzerland) · 2024Review
- LPS-DephosphorylatingMicroorganisms · 2024Article
- Bivalves Present the Largest and Most Diversified Repertoire of Toll-Like Receptors in the Animal Kingdom, Suggesting Broad-Spectrum Pathogen Recognition in Marine Waters.Molecular biology and evolution · 2023Article
- Lipid A structural diversity among members of the genusFrontiers in microbiology · 2023Article
- Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature.Open biology · 2022Review
- An innate ability: How do basal invertebrates manage their chronic exposure to microbes?PLoS pathogens · 2022Article
- Tetracyclines: four rings to rule infections through resistance and disease tolerance.The Journal of clinical investigation · 2022Article
- Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11.Infection and immunity · 2022Article
- Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation.Infection and immunity · 2022Article
- Lipid A Structural Determination from a Single Colony.Analytical chemistry · 2022Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 3 countries.
Anna E GauthierDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0001-5423-9752
Courtney E ChandlerDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.ORCID 0000-0003-2076-3665
Valentina PoliHarvard Medical School, and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA 02115, USA.ORCID 0000-0001-8637-8204
Francesca M GardnerDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.
Aranteiti TekiauMinistry of Fisheries, Republic of Kiribati, Tarawa, Kiribati.
Richard SmithDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.
Kevin S BonhamDepartment of Biological Sciences, Wellesley College, 106 Central St., Wellesley, MA 02481, USA.ORCID 0000-0003-3200-7533
Erik E CordesDepartment of Biology, Temple University, 1900 N. 12th St., Philadelphia, PA 19122, USA.ORCID 0000-0002-6989-2348
Timothy M ShankBiology Department, MS33, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.ORCID 0000-0002-5562-3964
Ivan ZanoniHarvard Medical School, and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA 02115, USA.ORCID 0000-0002-3423-7474
David R GoodlettDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.ORCID 0000-0002-8045-8200
Steven J BillerDepartment of Biological Sciences, Wellesley College, 106 Central St., Wellesley, MA 02481, USA.ORCID 0000-0002-2638-823X
Robert K ErnstDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.ORCID 0000-0001-5016-8694
Randi D RotjanDepartment of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA. jonathan.kagan@childrens.harvard.edu rrotjan@bu.edu.ORCID 0000-0002-3401-9784
Jonathan C KaganDivision of Gastroenterology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. jonathan.kagan@childrens.harvard.edu rrotjan@bu.edu.ORCID 0000-0003-2364-2746
University of Maryland, Baltimore · USBoston Children's Hospital · USBoston University · USWellesley College · USMinistry of Fisheries and Marine Resource Development · KITemple University · USWoods Hole Oceanographic Institution · US
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4MProject 2: Genes required for dendritic cell responses to pathogens and T cellsU19AI133524 · NIAID · HARVARD MEDICAL SCHOOL · PI SHARPE, ARLENE H. · 2017 to 2021
$12.3MInitiation and Regulation of Antiviral Innate ImmunityR01AI093589 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KAGAN, JONATHAN C · 2011 to 2020
$4.4MDefining the pathways activated by Toll-like Receptors to stimulate immunityR37AI116550 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI JONATHAN C KAGAN · 2021 to 2026
$3.3MMS Diagnostic Bacterial Identification LibraryR01AI147314 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2020 to 2024
$2.3MCharacterization of the myddosome, a protein complex that controls TLR signalingR01AI116550 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KAGAN, JONATHAN C · 2017 to 2020
$1.8MProtection Against Gram-Negative Sepsis Conferred by Lipid A-Based Structural VariantsR01AI123820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2016 to 2019
$1.5MInitiation and Regulation of Antiviral Innate ImmunityR56AI093589 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI KAGAN, JONATHAN C · 2021 to 2021
$531kNIAID NIH HHS R01 AI093589NIAID NIH HHS R01 AI116550NIAID NIH HHS R01 AI123820NIAID NIH HHS R01 AI147314NIAID NIH HHS R37 AI116550NIAID NIH HHS R56 AI093589NIAID NIH HHS U19 AI133524NIDDK NIH HHS P30 DK034854
Abstract
The assumption of near-universal bacterial detection by pattern recognition receptors is a foundation of immunology. The limits of this pattern recognition concept, however, remain undefined. As a test of this hypothesis, we determined whether mammalian cells can recognize bacteria that they have never had the natural opportunity to encounter. These bacteria were cultivated from the deep Pacific Ocean, where the genus
Indexed as
Host Microbial InteractionsMicrobiotaWater MicrobiologyAnimalsAquatic OrganismsBiomarkersCell LineHumansMiceOceans and SeasReceptors, Pattern RecognitionSeawaterSpecies SpecificityBiomarkersReceptors, Pattern Recognition
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.