ArticleScience immunology2021
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation.
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Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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58 citing papers in PubMed, 87 citations in OpenAlex.
- Advances in natural killer cell immunotherapy for hematologic malignancies.Cancer biology & therapy · 2026Review
- Next-generation natural killer cell therapy: bench to bedside and beyond.Signal transduction and targeted therapy · 2026Review
- Single-cell analysis of adaptive NK and CMV-specific T-cell dynamics after allogeneic HSCT.Blood advances · 2026Article
- Natural Killer Cell Dysfunction Is Emerging During Midlife Obesity.Aging cell · 2026Article
- The CREM-IL-15 axis: decoding the persistence-exhaustion paradox in NK cell immunotherapy.Cancer immunology, immunotherapy : CII · 2026Review
- Single-cell sequencing reveals NK cell dysregulation during chronic HIV infection and identifies transitional NK cell cytotoxicity related to HIV reservoir decay.EBioMedicine · 2026Article
- Bcl11b dose-dependently regulates positive selection of CD8 T cells to the virtual memory fate.bioRxiv : the preprint server for biology · 2026Article
- Persistent loss of intrahepatic IFN-γ in HBV is linked to selective impairment of liver-resident CXCR6+NK cells despite long-term NUC therapy.JHEP reports : innovation in hepatology · 2026Article
- BARTsc identifies key transcriptional regulators from single-cell omics data.bioRxiv : the preprint server for biology · 2026Article
- Conditional T and NK cell antagonism by a giant and highly conserved orthopoxvirus virulence factor.Research square · 2026Article
- Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements.European journal of immunology · 2026Article
- Article
- The transcription factor BCL11B drives NK cell cytotoxicity and antitumor activity.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Nanomaterials Trigger Functional Anti-Tumoral Responses in Primary Human Immune Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A human NK cell progenitor that originates in the thymus and generates KIRScience advances · 2025Article
- Phenotype and function of IL-10-producing NK cells in individuals with malaria experience.JCI insight · 2025Article
- Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.Genes & development · 2025Article
- T and NK cell functionality in a patient harboring heterozygous novel BCL11B p.Asp632fsAla∗91 and STX11 p.R129P mutations.Heliyon · 2025Article
- Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6.Cell death & disease · 2025Article
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Authors and funding
23 authors at 10 institutions in 4 countries.
Tim D HolmesBroegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, N-5021 Bergen, Norway. tim.holmes@uib.no yenan.bryceson@ki.se.ORCID 0000-0002-9348-3982
Ram Vinay PandeyCentre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.ORCID 0000-0001-7420-4346
Eric Y HelmDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-6128-5204
Heinrich SchlumsCentre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.ORCID 0000-0002-2895-7766
Hongya HanCentre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
Tessa M CampbellCentre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.ORCID 0000-0002-7737-2123
Theodore T DrashanskyDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-6215-1232
Samuel ChiangDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Cheng-Ying WuDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.ORCID 0000-0001-7765-9389
Christine TaoDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Moneef ShoukierPrenatal Medicine Munich, Munich, Germany.ORCID 0000-0002-9237-4696
Eva TolosaDepartment of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-5247-8378
Sandra Von HardenbergDepartment of Human Genetics, Hannover Medical University, Hannover, Germany.ORCID 0000-0002-3680-7450
Miao SunDivision of Human Genetics, Cincinnati Children's Hospital Medical Center College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.ORCID 0000-0002-3074-8330
Christian KlemannDepartment of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-5639-8690
Rebecca A MarshDivision of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Colleen M LauImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-7538-094X
Yin LinBaylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75246, USA.
Joseph C SunImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-8062-9033
Robert MånssonCentre for Hematology and Regenerative Medicine, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.ORCID 0000-0003-0738-0328
Frank CichockiDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.ORCID 0000-0003-3043-0653
Dorina AvramDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-1254-1122
Yenan T BrycesonBroegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, N-5021 Bergen, Norway. tim.holmes@uib.no yenan.bryceson@ki.se.ORCID 0000-0002-7783-9934
Karolinska University Hospital · SECincinnati Children's Hospital Medical Center · USUniversity of Florida · USMedizinische Hochschule Hannover · DEMemorial Sloan Kettering Cancer Center · USUniversity of Minnesota Medical Center · USBaylor University · USMoffitt Cancer Center · USMünchen Klinik · DEUniversität Hamburg · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTrial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Mark J Osborn · 1995 to 2026
$48.2MRole of Bcl11b in CD4+ T cells and innate lymphoid cellsR01AI067846 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA · 2007 to 2023
$6.2MTraining Program in Regenerative MedicineT32DK074367 · NIDDK · UNIVERSITY OF FLORIDA · PI SCOTT, EDWARD W · 2007 to 2022
$2.9MMolecular Programming of Immunological Memory in Human Natural Killer CellsR00HL123638 · NHLBI · UNIVERSITY OF MINNESOTA · PI CICHOCKI, FRANK · 2017 to 2019
$736kMolecular Programming of Immunological Memory in Human Natural Killer CellsK99HL123638 · NHLBI · UNIVERSITY OF MINNESOTA · PI CICHOCKI, FRANK · 2015 to 2016
$190kNCI NIH HHS P01 CA065493NCI NIH HHS P30 CA008748NHLBI NIH HHS K99 HL123638NHLBI NIH HHS R00 HL123638NIAID NIH HHS R01 AI067846NIDDK NIH HHS T32 DK074367
Abstract
Epigenetic landscapes can provide insight into regulation of gene expression and cellular diversity. Here, we examined the transcriptional and epigenetic profiles of seven human blood natural killer (NK) cell populations, including adaptive NK cells. The
Indexed as
AnimalsBiomarkersCell DifferentiationChild, PreschoolChromatin Assembly and DisassemblyEnhancer Elements, GeneticEpigenesis, GeneticGene Expression RegulationHLA AntigensHumansImmunophenotypingInfantKiller Cells, NaturalMiceMice, KnockoutReceptors, KIRBCL11B protein, humanBcl11b protein, mouseBiomarkersHLA AntigensReceptors, KIRRepressor ProteinsTumor Suppressor Proteins
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