ArticleDevelopment (Cambridge, England)2021
A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome.
Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- The impact of alignment and scaling on biological inferences from landmark-free morphometrics.Journal of anatomy · 2026Article
- Cracking the Code: Computational Image Analysis Tools for Histopathological and Morphometric Insights.Journal of imaging · 2026Review
- Fifteen years of the Diversity Outbred mouse model: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Ripply3 overdosage induces mid-face shortening through Tbx1 downregulation in Down syndrome models.PLoS genetics · 2025Article
- Assessing the application of landmark-free morphometrics to macroevolutionary analyses.BMC ecology and evolution · 2025Article
- Personalized Joint Replacement: Landmark-Free Morphometric Analysis of Distal Radii.Journal of functional morphology and kinesiology · 2025Article
- How many specimens make a sufficient training set for automated three-dimensional feature extraction?Royal Society open science · 2024Article
- Large deformation diffeomorphic mapping of 3D shape variation reveals two distinct mandible and head capsule morphs inEcology and evolution · 2024Article
- Opportunities and Challenges in Applying AI to Evolutionary Morphology.Integrative organismal biology (Oxford, England) · 2024Review
- Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome.Neurobiology of disease · 2023Article
- A landmark-free analysis of the pelvic girdle in Sulawesi ricefishes (Adrianichthyidae): How 2D and 3D geometric morphometrics can complement each other in the analysis of a complex structure.Ecology and evolution · 2023Article
- Beak morphometry and morphogenesis across avian radiations.Proceedings. Biological sciences · 2023Article
- Pervasive cortical and white matter anomalies in a mouse model for CHARGE syndrome.Journal of anatomy · 2023Article
- Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice.JCI insight · 2023Article
- Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes.Development (Cambridge, England) · 2023Article
- A Comparison of Semilandmarking Approaches in the Analysis of Size and Shape.Animals : an open access journal from MDPI · 2023Article
- Morphometric analysis of the size-adjusted linear dimensions of the skull landmarks revealed craniofacial dysmorphology in Mid1-cKO mice.BMC genomics · 2023Article
- Automated morphological phenotyping using learned shape descriptors and functional maps: A novel approach to geometric morphometrics.PLoS computational biology · 2023Article
- Green Tea Catechins Modulate Skeletal Development with Effects Dependent on Dose, Time, and Structure in a down Syndrome Mouse Model.Nutrients · 2022Article
- MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.Scientific data · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Characterising phenotypes often requires quantification of anatomical shape. Quantitative shape comparison (morphometrics) traditionally uses manually located landmarks and is limited by landmark number and operator accuracy. Here, we apply a landmark-free method to characterise the craniofacial skeletal phenotype of the Dp1Tyb mouse model of Down syndrome and a population of the Diversity Outbred (DO) mouse model, comparing it with a landmark-based approach. We identified cranial dysmorphologies in Dp1Tyb mice, especially smaller size and brachycephaly (front-back shortening), homologous to the human phenotype. Shape variation in the DO mice was partly attributable to allometry (size-dependent shape variation) and sexual dimorphism. The landmark-free method performed as well as, or better than, the landmark-based method but was less labour-intensive, required less user training and, uniquely, enabled fine mapping of local differences as planar expansion or shrinkage. Its higher resolution pinpointed reductions in interior mid-snout structures and occipital bones in both the models that were not otherwise apparent. We propose that this landmark-free pipeline could make morphometrics widely accessible beyond its traditional niches in zoology and palaeontology, especially in characterising developmental mutant phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.