Evidence map›Paper›PMID 33712037›Full record

ArticleItalian journal of pediatrics2021

Incidence and risk factors of retinopathy of prematurity in an Italian cohort of preterm infants.

Carlo Dani, Caterina Coviello, Fiorenza Panin, Saverio Frosini, Simonetta Costa, Velia Purcaro, Domenico Lepore, Giovanni Vento

Open access · goldAbstract read
In one paragraph

Article in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 47 citations in OpenAlex.

  1. [Predictive factors for retinopathy of prematurity in a hospital from Bajío].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Article
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  3. Involving neonatal hematology and transfusion medicine in global efforts to eliminate severe retinopathy of prematurity.Journal of perinatology : official journal of the California Perinatal Association · 2025
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  14. Systemic Cytokines in Retinopathy of Prematurity.Journal of personalized medicine · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Carlo DaniDivision of Neonatology, Careggi University Hospital, Largo Brambilla 3, 50141, Florence, Italy. cdani@unifi.It.
Caterina CovielloDivision of Neonatology, Careggi University Hospital, Largo Brambilla 3, 50141, Florence, Italy.
Fiorenza PaninDivision of Neonatology, Careggi University Hospital, Largo Brambilla 3, 50141, Florence, Italy.
Saverio FrosiniEye Clinic, Neuromuscular and Sense Organs Department, Careggi University Hospital, Florence, Italy.
Simonetta CostaDivision of Neonatology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of Sacred Heart, Rome, Italy.
Velia PurcaroDivision of Neonatology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of Sacred Heart, Rome, Italy.
Domenico LeporeDepartment of Ophthalmology, Gemelli Foundation IRCSS, Catholic University of the Sacred Heart, Rome, Italy.
Giovanni VentoDivision of Neonatology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of Sacred Heart, Rome, Italy.
Azienda Ospedaliero-Universitaria Careggi · ITAgostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNon-negligible differences in retinopathy of prematurity (ROP) and its risk factors between different neonatal intensive care units (NICUs) are reported. Our aim was to assess the incidence and risk factors for ROP development in a large cohort of very preterm infants who were assisted in two Italian NICUs.

methodsPreterm infants with gestational age between 23

resultsWe studied a total of 178 infants of whom 67 (38%) developed ROP (stage 1: n = 12; stage 2: n = 41; stage 3: n = 14). Regression analysis demonstrated that maternal milk (OR 0.979, 95% Cl 0.961-0.998) decreased the risk of developing ROP, while intraventricular hemorrhage (IVH) (OR 2.055, 95% Cl 1.120-3.772) increased it. Moreover, maternal milk was found to decrease (OR 0.981, 95% Cl 0.964-0.997) the risk of ROP at discharge, while RBC transfusion increased it (OR 1.522, 95% Cl 1.208-1.916).

conclusionsIn our cohort the occurrence of ROP was similar to that previously reported. Strategies for promoting the use of mother's own milk, preventing IVH, and standardizing the approach to RBC transfusions could contribute to decreasing the risk of ROP in very preterm infants.

Indexed as

Infant, PrematureCohort StudiesFemaleHumansIncidenceInfant, NewbornIntensive Care Units, NeonatalItalyMaleRetinopathy of PrematurityRisk FactorsHuman milkInterventricular hemorrhagePreterm infantsRetinopathy of prematurityRisk factors

Identifiers

PMID33712037
PMCPMC7953747
OpenAlexW3135649023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.