Evidence map›Paper›PMID 33711998›Full record

ArticleBMC complementary medicine and therapies2021

Evaluation of expression and serum concentration of anti-Mullerian hormone as a follicle growth marker following consumption of fennel and flaxseed extract in first-generation mice pups.

Fahimeh Pourjafari, Tahereh Haghpanah, Fariba Sharififar, Seyed Noreddin Nematollahi-Mahani, Ali Afgar, Massood Ezzatabadipour

Open access · goldAbstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fahimeh PourjafariAnatomical Sciences Department, School of Medicine, Kerman University of Medical Sciences, P.O. Box:76169-14115, Kerman, Iran.
Tahereh HaghpanahAnatomical Sciences Department, School of Medicine, Kerman University of Medical Sciences, P.O. Box:76169-14115, Kerman, Iran.
Fariba SharififarHerbal and Traditional Medicines Research Center, Department of Pharmacognosy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Seyed Noreddin Nematollahi-MahaniAnatomical Sciences Department, School of Medicine, Kerman University of Medical Sciences, P.O. Box:76169-14115, Kerman, Iran.
Ali AfgarResearch Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran.
Massood EzzatabadipourAnatomical Sciences Department, School of Medicine, Kerman University of Medical Sciences, P.O. Box:76169-14115, Kerman, Iran. ezzatabadipm@gmail.com.ORCID http://orcid.org/0000-0003-2738-3171
Kerman University of Medical Sciences · IR

Funding

Kerman University of Medical Sciences 95000699
6 · The paper itself

Abstract

backgroundThe aim of the present study was to assess the expression and serum level of AMH in first-generation female mice pups following fennel and flaxseed consumption.

methodsTwenty pregnant NMRI mice were allocated into four groups including control (CTL), fennel (FV), flaxseed (LU) and FV+ LU. Sixty-four female offsprings after lactation period, received the same regimen as their mothers for 56 and 240 days. The ovarian follicles development, serum concentration of AMH, as well as gene and protein expression of AMH were evaluated in the female offsprings at post-natal day 56 (PND56) and 240 (PND240).

resultsThe number of total growing follicles were raised in the FV group in compression to the all experimental groups. In contrast, LU group showed a marked decrease in their numbers. The highest level of serum AMH was seen in the FV-diet mice, whereas LU negatively affected it. The expression level of AMH also increased in the FV and FV + LU groups, while a reduction was observed in the LU group. As well, IHC data showed that the number of AMH-positive cells in almost ovarian follicles of FV and FV + LU-treated mice was in compared to those of the LU group.

conclusionsThe overall effect of fennel treatment (alone and in combination with flaxseed) on ovary might be maintain primordial follicle storage through increased expression and serum level of AMH.

Indexed as

FlaxFoeniculumAnimalsAnimals, NewbornAnti-Mullerian HormoneFemaleIranMiceOvarian FolliclePlant ExtractsPregnancyAnti-Mullerian HormonePlant ExtractsAnti-Müllerian hormoneFennelFirst-generation mice pupsFlaxseedOvarian follicular growth

Identifiers

PMID33711998
PMCPMC7953604
OpenAlexW3133892949

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.